In general, our facilty has over 120 staff in the IS dept which is pretty good for a large metropolitan area. Of the staff - not one has a degree specifically in informatics. The two nurses hired with the title of informaticist both came from Education and have a BSN. As a pure informaticist, you actually don't do the high volume of technical work (ie server support, databases, interfaces etc..) this type of work is typically performed by the technical staff.
I am not an informaticist nor are the 4 other nurses working with me - we are systems analysts . This is the distinction. As a systems analyst, you are not limited to purely clinical projects involving nursing and providers. I have worked on various software implementations for our dietary dept, bed management dept, ehr upgrades, rehab, respiratory, lab, meaningful use etc.. None of which utilized my nursing patient care background specifically; however my knowledge of the healthcare systems and the workflows is what is valued not so much my patient care experience. The informaticist tend to focus more on nursing and provider workflows (documentation, order entry etc..)
My issue with focusing nursing informatics as opposed to healthcare information systems is eventually most facilities will have implemented documentation, barcoding, cpoe etc.. There is a pretty good market now. I have seen many institutions bring on consultant for 6 mos stints with these implementations but not necessarily hire for informaticists. They tend to hire for analysts with technical skills such as interfaces, report writing, sql, etc..
nice way to see what is available is to search the job postings of various hospitals filtering for information systems - there are very few postings specifically for informatics. Your informatics posting are usually posted in the Education dept as technical trainers.
As far as other positions, it's tricky without demonstrated experience - some of the nurses I have worked with tended to work within hospitals, case management, research etc..
Research (in addition to Education) is also a good place to transition from if you can.