In the 15 years i have done PICCs and midlines, i have used PICC catheters and trim them to become midlines per INS definition. The PICC catheters are trimable catheters , so i do not see any reason why not. Of course, your rep is going to tell you not to trim their PICC catheters because they need to have more sales... Except if you use a groshong double lumen you cannot trim the catehter. If there is any research out their, i have not encountered any. How are my patients, i have had no adverse report so far. I know, once i had a discussion with another nurse who told me that i should not be trimming the PICC catheter becase she says her rep told her to order midline catheters. She told me that the label of the PICC catheter says PICC Not midlines and this will cause nurses to mistakenly use the line for a vesicant. I said then the nurses should make sure they look at at the kardex or the nurses notes of the person doing the procedure for the tip position or better yet, look at the chest xray film..