I really think it depends on your professor and how difficult they want to make it. Both classes are pretty intense. If you are just coming out of Anatomy, then Physio may be the way to go since things are fresh in your mind . In Anatomy you learned what the different systems were, so in Physio you will learn about how the different systems work (hormones, electrolytes, etc.). I did better in Micro than Physio. I took Micro in the summer, so there was not a lot of time for any extra projects. My Physio class was insane. There were papers, presentations, projects; in addition to the normal labs and lecture. It was a seemingly never-ending roller coaster.