Start with the complaints commonly seen on these boards. Nurse/Pt ratios, inadequate and shortened orientations, unhelpful or worse response from those with experience on the unit.
The solution to these complaints is an organizational committment to nurses, not just new ones.
For a start, make new employee satisfaction a significant part of the performance reviews of charge nurses, unit managers, and up the line.
I'm a new grad, although with quite a few miles on me in other industries, and I work in transplant. For the record, I'm being given a very good orientation, despite changes in personnel in our unit. I very much enjoy my job. Sure, I feel stressed and dumb at times, but that comes with the territory of any new job. The thing is, I have people I can turn to.
One thing often missing from this type of discussion is the part the newbie can play in enlisting the staff as friends, rather than critics. Be friendly, be respectful, never carry tales, and jump in and help with the mundane tasks without being asked. As a newbie I know I can't carry a full load, but I can make sure I do carry the load I can.