I can't comment on the nursing aspect of living in SF, cause I am still a student nurse, but I have lived in the SF area all my life and there is a lot to consider. It is very easy to fall in love with SF. Its a fun, exciting, eventful place but it can also be a really scary place. Like pp mentioned, rental prices are astronomical and crime is skyrocketing. With opiates being such an epidemic right now, homelessness and the crimes in order to pay for their addictions are skyrocketing as well. There is a lot of gang activity and that carries over into the schools, so if you plan to have children that is something to consider. Most streets smell like urine, you will see people pooping or shooting up right on the sidewalk...Its definitely not an all rainbows and sunshine city. Don't get me wrong, I love SF but you might want to spend an extended amount of time there before you make the decision to move. Personally, I've always loved Berkeley more than SF and Oakland is actually becoming a really nice city as well with excellent hospitals.
I don't want to scare you, just wanted you to know the bad points about SF as it is really easy to get caught up in all the great parts about it.