Great question. So we do try to limit how many times we access the central line to decrease the risk of a CLABSI. We *try* to access it no more than x3/24 hours. However as you said, often the need to more frequently access an invasive line increases as a patient's acuity changes/increases...eg q4hr labs results in x6 times/day. Trying to "cluster" your lab draws/invasive line interventions helps to cut down on the number of times you access the line. We also utilize green Curos disinfecting caps, daily CHG baths, and meticulous dressing changes/line care to try to cut down on CLABSI rates.
A key issue is that often we have multiple types of invasive lines & devices in one patient eg: trialysis, double lumen CVC, MAC or venous sheath with swan ganz, arterial lines, arterial-sheaths with a balloon pump/Impella/etc, PICC's, IO, ports, permacaths, etc...so infection concern applies when accessing all of the invasive lines in a patient.