NIH Panel Counters FDA: No Solid Data on Convalescent Plasma for COVID-19

[NRSKarenRN, BSN, RN]

Medscape Medical News  9/02/2020

NIH Panel Counters FDA: No Solid Data on Plasma for COVID-19

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Current data are insufficient to recommend either for or against using convalescent plasma to treat patients who have COVID-19, the National Institutes of Health's (NIH) COVID-19 Treatment Guidelines Panel said Tuesday.

"Convalescent plasma should not be considered standard of care for the treatment of patients with COVID-19," the committee said.

The COVID-19 Treatment Guidelines Panel, made up of physicians, statisticians, and other experts, rejected that interpretation of the data.

"[Though data suggest that convalescent plasma with high antibody titers may be beneficial in nonintubated patients, uncertainty remains about the efficacy and safety of convalescent plasma due to the lack of a randomized control group and possible confounding," the NIH panel concluded after reviewing published and unpublished data on convalescent plasma for treating COVID-19, including the FDA analyses that led to the EUA.

The panel notes that serious adverse reactions after the administration of COVID-19 convalescent plasma are infrequent, which is "consistent with the risks associated with plasma infusions for other indications."

https://www.medscape.com/viewarticle/936767

Full NIH: Statement on Convalescent Plasma EUA

https://www.covid19treatmentguidelines.nih.gov/statement-on-convalescent-plasma-eua/