iv fluid

I am assuming D5W...but, why would you combine normal saline with D5W?

Why mix them, when you can grab a bag of D5NS off the shelf?

b/c i have drug mixed in D5W 100 ml and i need to dilute it to 500 ml or more to infuse it in 3 hr

Clearly this is a homework question. Students are asked to do their own research and show their work first rather than just posting your homework for other people to do. So... what do your drug guide say? What makes a solution hyper or hypo tonic?

i know but in asking is this correct and whats the solution become?

I will help you but you have to answer some questions for me:

1) What is NS? What makes it "normal?"

2) What is D5W? What does the 5 indicate?

3) What are the definitions of hypotonic, isotonic, and hypertonic?

4) How do you calculate dilutions?

Once you answer those, you very likely will be able to answer your own question but if not, I will guide you from there (as will everyone else, I'm sure)

b/c i have drug mixed in D5W 100 ml and i need to dilute it to 500 ml or more to infuse it in 3 hr

Maybe other people have seen it...but, I personally have NEVER seen a medication with a base of D5W then asked to dilute it further in normal saline. You're mixing two different solutions together (an isotonic and isotonic TO hypotonic).

What is the drug? And I'm assuming this is a homework assignment, so why not post the entire question?

I will help you but you have to answer some questions for me:

1) What is NS? What makes it "normal?"

2) What is D5W? What does the 5 indicate?

3) What are the definitions of hypotonic, isotonic, and hypertonic?

4) How do you calculate dilutions?

Once you answer those, you very likely will be able to answer your own question but if not, I will guide you from there (as will everyone else, I'm sure)

1.NS is a solution contain sodium chloride 0.9 % in 500 ml sterile water, it normal b/c it isotonic

2.D5W is sterile water contains 5 % dextrose in 500 ml , 5 indicate contains 5 gm dextrose

3. hypotonic: is solution that withdrawn fluid from extracellular to inside of cells

isotonic : have the same osmolarity as plasma so its only expand plasma

hypertonic: is solution that withdrawn fluid from cells extracellular part

4. i did not known this Q

if you known p/z tell

Maybe other people have seen it...but, I personally have NEVER seen a medication with a base of D5W then asked to dilute it further in normal saline. You're mixing two different solutions together (an isotonic and isotonic TO hypotonic).

What is the drug? And I'm assuming this is a homework assignment, so why not post the entire question?

its not homework assignment .

i have chemotherapy paclitaxel store it in D5W b/c it stable in it but when we need to give him to the patient we should further dilute it in NS so in want to known if this mixing is correct or not

OK. I think I see what you are trying to do. I looked it up in my Davis' Drug Guide app on my phone.

It states:

Paclitaxel must be diluted prior to injection. Diluent: Dilute contents of 5mL (30mg) vials with the following diluents: 0.9% NS, D5W, D5NS, or dextrose in Ringer's Solution. You also need to use an in-line filter of not >0.22micron pore size.

According to that, you do not need to dilute it any further as you've already added the diluent.

If you are STORING it after diluting it, you do NOT further dilute it. It is only stable for 27 hours at room temperature and lighting.

OK. I think I see what you are trying to do. I looked it up in my Davis' Drug Guide app on my phone.

It states:

Paclitaxel must be diluted prior to injection. Diluent: Dilute contents of 5mL (30mg) vials with the following diluents: 0.9% NS, D5W, D5NS, or dextrose in Ringer's Solution. You also need to use an in-line filter of not >0.22micron pore size.

According to that, you do not need to dilute it any further as you've already added the diluent.

If you are STORING it after diluting it, you do NOT further dilute it. It is only stable for 27 hours at room temperature and lighting.

i have high concentration 250 mg with require more fluid , i asking is this mixing is correct? and whats the solution become

Needs to be diluted by about 42mL of your specific diluent.

Drug:Paclitaxel - Taxol® Oncology -

Intravenous Dilution Data