Gentamicin Question

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I have a question about Gentamicin? As in the Drug Handbook it states "The concentration of gentamicin in the solution should not exceed 1mg/mL". I would like to understand if the prescribed dose is 320mg how do I work out how much fluid it needs to be administered in?

Look forward to your helpful replies, as I find both Vancomycin and Gentamicin dosing confusing, thank you:confused:

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Specializes in CTICU.

The dose is 320mg and you need 1mg/ml. So you need 1 ml per 1mg.

....then you need 320ml, right?

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Specializes in ICU/ER.

320 ml, may be further diluted.

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Specializes in home health, dialysis, others.

This sounds like a very high dose to me, but 320 ml would be the minimum. Are you sure that 320mg is one dose? Or is it 80 mg every 6 hours? Please double-check.

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Specializes in Emergency Department.

Would this be an intravenouse drip solution?

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Specializes in CTICU.
This sounds like a very high dose to me, but 320 ml would be the minimum. Are you sure that 320mg is one dose? Or is it 80 mg every 6 hours? Please double-check.

Gentamicin can be dosed once-daily or even at a larger dosing interval, up to 7mg/kg dose. I have often given 320mg doses in ICU pts.

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I'd check with your pharmacist since gent must be dosed very carefully.

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Yep its a once off dose for 320mg IV

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