Co-administration of Zyvox and albuterol?

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Specializes in Med/Surg, Geriatric, Hospice.

We received a notice from pharmacy on a patient prescribed the antibiotic linezolid (Zyvox) and albuterol inh, referring to MAOI's (that linezolid apparantly has MAOI-type properties?) interacting with albuterol and should not be used concurrently, or within 14 days of one another. (Which I am aware is the standard for MAOI's and interacting medications).

I thought only anti-depressants/anti-anxiety drugs were MAOI's? I guess I am mistaken.. or is it that linezolid has MAOI-like properties and can cause such a reaction? Anyone have any experience with this? Or had any patients with reactions while using linezolid?

(There were no other diet recommendations/restrictions from pharmacy or the Dr. for this patient regarding the linezolid).

Just wanted to see others' experiences! Thanks.

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Yes, Linezolid is a monoamine-oxidase inhibiter but it's a weak one.

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This is actually very interesting as this is the second thing I've seen detrimental from Zyvox. I just recently took care of a patient that had a communication stating that a b vitamin (6? 12?) needed supplementation while on Zyvox due to its function in the body...

That said, I've never heard that, no.

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What is the adverse reaction Zyvox (or any MAOI) and albuterol cause?

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Specializes in Anesthesia, CTICU.
We received a notice from pharmacy on a patient prescribed the antibiotic linezolid (Zyvox) and albuterol inh, referring to MAOI's (that linezolid apparantly has MAOI-type properties?) interacting with albuterol and should not be used concurrently, or within 14 days of one another. (Which I am aware is the standard for MAOI's and interacting medications).

I thought only anti-depressants/anti-anxiety drugs were MAOI's? I guess I am mistaken.. or is it that linezolid has MAOI-like properties and can cause such a reaction? Anyone have any experience with this? Or had any patients with reactions while using linezolid?

(There were no other diet recommendations/restrictions from pharmacy or the Dr. for this patient regarding the linezolid).

Just wanted to see others' experiences! Thanks.

Haven't had the chance to research it, but I've been told concommitant infusion of Zyvox and phenylephrine can cause uncontrolled hypertension...

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