Cholinergic Crap

I learned that E and NE are adrenergic/catecholamines and of the SNS not parasympathethic(which is cholinergic). Ach is for PSNS. Just finished the patho /pharm test today. My teacher did not differentite btwn alpha 1 & 2. But it was easy to remember that alpha was for puils and blood vessels, Beta1 is for heart(because you only have one heart), Beta2 is for lungs(coz you got 2 of those). Those functions you listed are the same as what I learned.

Agonists are going to copy/mimic what the body normally does. Whether it be SNS or PSNS. Antagonist are going to block or inhibit those normal responses. In a sense, SNS antagonists/blockers are going to act like PSNS and PSNS antagonist/blockers are going to act like SNS

hope this makes sense

i think epi and neroepi are adrenergic...they stimulate the sympathetic nervous system.

you should add the urinary system also :)

ok, this is what i learned, but don't laugh at me, k?

adrenergic (sympathetic): fight or flight response

nts: norepinephrine, epinephrine, dopamine

what happens with this response when you face a bear in the woods? you hr & bp speeds up (scared), gi/bladder motility slows down (no time to poop or pee while running from said bear), coronary artery vasodilation & peripheral vascular constriction (more blood to heart & brain so you can think of place to hide from bear), relaxes bronchial smooth muscles (more oxygen to assist in running).

side effects of most adrenergic drugs: mimic hangover effects from adrenaline rush (tachycardia, palpitations, tremors, h/a, htn etc.)

two classes:

1. catecholamines (think of how catwoman makes batman feel): these work fast; used for shock, cardiac arrest, severe hypotension)

2. noncatecholamines (this is batman, cool & collected): these work slower, longer lasting; used for bronchospasm, nasal congestion, pre-term labor

alpha receptors:

alpha 1: vasoconstricts arteries, relaxes bladder

alpha 2: pancreas, skeletal blood vessels

*both constrict arteries, therefore, all alpha = artery constriction

beta receptors:

beta 1 (1 heart): increased hr & contraction strengh

beta 2 (2 lungs): relaxes smooth muscle of bronchi & uterus

* beta = beating & breathing

adrenergic blocking agents (antiadrenergic):

once you understand the above, this is simply the exact opposite. you need to think of it in terms of "blocking the fight/flight response".

cholinergic (parasympathetic): rest & digest response

nts:acetylcholine

this system lets you rest & digest: constricts pupils (sleepy), increases gi motility/bladder muscle tone (now you can poo/pee), increases secretions, decreases hr, constricts bronchial smooth muscle.

s/e of these drugs: n/v/d, bradycardia, hypotension etc. since the drug is enhancing this system, your s/e are exacerbations of rest/digest.

anticholinergic:

again, exact opposite of rest/digest since you are now "blocking" this system.

whew. i only scratched the surface & typed fast. hopefully, someone will have more to add. good luck to you!

Hey guys thanks for th responses i wanted to add that the Neurotransmitter part.. i had copied and pasted this from Microsoft word and it pasted it wrong. I know the difference btw NT of the PS and Symp system.

What is the nicotinic and muscarinic part tho??

Hey guys thanks for th responses i wanted to add that the Neurotransmitter part.. i had copied and pasted this from Microsoft word and it pasted it wrong. I know the difference btw NT of the PS and Symp system.

What is the nicotinic and muscarinic part tho??

Nicotinic and muscarinic are acetycholine receptors each of them work on different areas.

That do what tho?

That do what tho?

Here is a good explanation of these receptors.

http://www.ebi.ac.uk/interpro/potm/2005_11/Page2.htm