Jump to content

amiodarone-diflucan contraindication?

Nurses   (7,947 Views 10 Comments)
by lovingRN2009 lovingRN2009 (New Member) New Member

lovingRN2009 has 4 years experience .

1,327 Visitors; 24 Posts

advertisement

ever heard of these two meds together a big no-no?

Share this post


Link to post
Share on other sites

netglow works as a RN.

33,507 Visitors; 4,412 Posts

Epocrates says: Avoid combo: combo may incr. amiodarone levels, risk of QT prolongation, cardiac arrhythmias (hepatic metab. inhibited; additive effects, some azole antifungals may prolong QT)

Share this post


Link to post
Share on other sites

netglow works as a RN.

33,507 Visitors; 4,412 Posts

Medscape says: Amiodarone and Fluconazole both increase QTc interval. Never use combination. Fluconazole will increase the level or effect of Amiodarone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Significant interation possible, monitor closely.

Share this post


Link to post
Share on other sites

lovingRN2009 has 4 years experience.

1,327 Visitors; 24 Posts

thanks, i was able to find this info online. what i'm trying to find out is if this is common knowledge to the majority or if nurses see these given together without reservation.

Share this post


Link to post
Share on other sites

netglow works as a RN.

33,507 Visitors; 4,412 Posts

Sorry :lol2: just playing with my itouch... got Epocrates, Medscape and Davis on it.

Share this post


Link to post
Share on other sites

lovingRN2009 has 4 years experience.

1,327 Visitors; 24 Posts

no problem- had you ever heard of it before looking it up just now?

Share this post


Link to post
Share on other sites
advertisement

18,753 Visitors; 2,334 Posts

I've "always" known not to give them together unless there is absolutely no other option.

Share this post


Link to post
Share on other sites

lovingRN2009 has 4 years experience.

1,327 Visitors; 24 Posts

with amiodarone having such a long half life, what is an appropriate time to wait between stopping amiodarone, starting diflucan and restarting amiodarone?

Share this post


Link to post
Share on other sites

4,161 Visitors; 255 Posts

The half life of amiodarone is highly variable, but it's usually listed in terms of days or weeks rather than hours, so holding the amio while you infuse the diflucan wouldn't really be of any benefit.

Share this post


Link to post
Share on other sites

netglow works as a RN.

33,507 Visitors; 4,412 Posts

Nope, would have looked it up because I do know about Diflucan being a trouble maker.

Share this post


Link to post
Share on other sites
  • Recently Browsing 0 members

    No registered users viewing this page.

×