promising new weapon in fight against H5N1

oramar · Feb 27, 2010

Sorry I can't get this link to work, it was really interesting story about a new anti-h5n1 drug. I really tried. Might as well cancel it.

wowza · Mar 1, 2010

http://www.reuters.com/article/idUSTRE61P07I20100226

I bet this is what they were talking about. It seems similar to many of the things we already use for flu like zanamivir and peramivir.

indigo girl · Mar 2, 2010

http://afludiary.blogspot.com/2010/02/assessing-new-antiviral.html

here is more on the study about that drug. kind of exciting considering who the researchers are, and we desperately need this drug:

efficacy of the new neuraminidase inhibitor cs-8958 against h5n1 influenza viruses
maki kiso, shuku kubo, makoto ozawa, quynh mai le, chairul a. nidom, makoto yamashita, yoshihiro kawaoka
at least two of the authors listed above should be familiar names to readers of this blog; yoshihiro kawaoka and c. a. nidom.
abstract
cs-8958 functions as a long-acting na inhibitor in vivo (mice) and is efficacious against seasonal influenza strains following a single intranasal dose. here, we tested the efficacy of this compound against h5n1 influenza viruses, which have spread across several continents and caused epidemics with high morbidity and mortality.
we demonstrated that r-125489 interferes with the na activity of h5n1 viruses, including oseltamivir-resistant and different clade strains. a single dose of cs-8958 (1,500 µg/kg) given to mice 2 h post-infection with h5n1 influenza viruses produced a higher survival rate than did continuous five-day administration of oseltamivir (50 mg/kg twice daily).

for more info on the authors see: https://allnurses.com/pandemic-flu-forum/kawaoka-hybrid-swine-458348.html