Dilaudid and Psych patient

Nurses General Nursing

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i am a new nurse.

i had a patient who was admitted for medical reasons. this patient had an extensive psych history. i finally got admission orders and pain medication 4 hours after the patient had arrive to the floor. i medicated the patient with dilaudid 2mg iv. it was iv pushed over 5 minutes. the policy at my work place allows dilaudid 2 mg iv to be iv pushed in 2-3 minutes. in a couple of minutes,the patient's eyes closed, tacypnea, pupils dilated & slowly responive to light, and became nonverbal. to make it short... i gave narcan 0.4mg iv and was not effective. ativan 0.5mg iv was given and was not effective. benadryl 25 mg iv was given and was not effective. i had to transfer this patient to the icu because of hyperventaliation.

i was simply medicating my patient for c/o pain. this was the first dose given. i don't know what happen. is there an interaction between seroquel and dilaudid? did dilaudid trigger something neuro wise like the neurotransmitters? was it an allergic reaction? or dilaudid was too much for the patient eventhough the adverse effects were opposite of narcotics?

psych patients do some weird stuff.

Specializes in Ortho, Case Management, blabla.
Is it possible that the dose was incorrect (perhaps 4mg was administered instead)?

dilaudid generally comes in a 2mg bottle...it's kind of hard to screw up

This is what I found for interactions between Dilaudid and Seroquel

http://www.drugs.com/drug-interactions/seroquel_d04220_dilaudid_d00255.html

this is a list of all the drug/drug interactions for dilaudid.

http://www.drugs.com/drug-interactions/seroquel_d04220.html

As for NMS, there would have been massive muscle regitiy and would require emergent care. You would not be able to open there hand.

For EPS, alot of different things but mostly movement issues. Not easy for you to see in the situation but tachypnea would not be part of that.

As for the high dose, I have over ten pts on my floor with doses above 800mg/day, the highest is 1600mg/day(on a bad day) 900mg/day scheduled (300mg tid) and q4h 100mg prn. It's not uncommon for that pt to need that as well. (head trauma and extremely violent, been there 6 years)

So frankly after all that it has me pretty puzzled.

Thank you for this interesting puzzle. I will ask around.

Specializes in Emergency.
dilaudid generally comes in a 2mg bottle...it's kind of hard to screw up

Where I work, dilaudid comes in both 2mg/ml and 4mg/ml bottles. Just thought I'd ask if the dosing was correct, since higher doses may need more narcan (and perhaps this is why the 0.4mg administered narcan didn't work).

I'm thinking the dilaudid had caused mydriasis and tachypnea, and the amount of narcan given wasn't sufficient - and therefore, the narcan's effects weren't noted. (Perhaps your original thought was correct: "[the] Dilaudid was too much for the patient even though the adverse effects were opposite of narcotics".)

From Abbott's website: "Marked mydriasis rather than miosis may be seen with hypoxia in the setting of dilaudid overdose."

(http://www.rxabbott.com/pdf/dilaudid.pdf)

About Narcan dosing: "An initial dose of 0.4 mg to 2 mg of naloxone hydrochloride may be administered intravenously. If the desired degree of counteraction and improvement in respiratory functions is not obtained, it may be repeated at 2 to 3 minute intervals(http://www.drugs.com/pro/narcan.html).

In patients with opiate overdose that present to the ED, I've always initially given 2mg of narcan (never administered less, except for opiate OD in children).

Regarding narcotic induced toxicity: "Reliance on pupillary miosis to diagnose opioid intoxication can be misleading. If sufficiently severe, hypertension and pupillary dilation may present because of CNS hypoxia." (http://www.emedicine.com/EMERG/topic330.htm).

Additionally, some online literature that I read stated that bronchospasm and tachypnea are rare adverse reactions to dilaudid (http://www.massgeneral.org/pharmacy/icu%20Guidelines/hydromorphone.htm)

Specializes in Psychiatric.

How long was the interval between the time the patient took the dose of Seroquel and the time the Dilaudid was given? Seroquel has a half-life of 6 hours, so unless the two were given fairly close together I doubt they interacted badly...this is assuming the patient's liver is in decent working order, and this dose of Seroquel is not outside the therapeutic range...most patients with schizophrenia are maintained on this kind of dose...I think this patient simply had some sort of reaction to Dilaudid...then again, I would want more information about this patient to form a more accurate clinical picture...

Specializes in Adult health, Primary care, WH..

The patient took Seroquel that morning at home.... 8-9ish. I gave Dilaudid at 1915.

Specializes in Mursing.

Looks like you got a toughy one, tampa! Sorry I can't be of any assistance, but this is quite the learning experience for us all. And for that, I thank you.

If it makes you feel any better, I watched two nurses (shift change) do the same thing with my anorexic friend recently. I took her to the ER for the entire night and she managed to get dilaudid the entire time, despite my friends dropping heart rate. I learned my lesson on that trip to the ER and made sure it didn't happen the next two times.

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