I agree with suzanne4, you should be working at a level I trauma center, either in ER or trauma ICU. If you can be in a hospital that has their own flight program it may be beneficial since programs often fill the very few positions internally first. After experience, the key is certifications. ACLS, PALS, NRP, ENPC, TNCC, PHTLS. Some states require nurses to have their EMT or EMT-P. A national cert. such as CCRN or CEN is highly recommended if not required.
I can't give you any specifics about SC, but check out www.flightweb.com
If you click on 'links' you will find 'flight programs' which will list the programs available in SC. There is also a job board but this is not an all-inclusive list. Good luck.