Thanks for the advice. I've already spoken to both of them previously and told them I think they have a problem. They disagree and wouldn't consider any form of intervention or rehabilitation. I think I'll keep this matter between us and keep the BON out of it. I've known both of these women for 5 years and hope they know what they are doing. For the record....they do not practice in Alabama. They practice in California.
Here is the only pharmacodynamic information I could find on ecstasy.
3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) is a synthetic amphetamine derivative commonly abused by young people. There are only limited data about its pharmacokinetics and pharmacological effects under controlled conditions in humans. A series of studies were carried out to determine the pharmacokinetic and pharmacodynamics of MDMA. All studies were placebo-controlled, randomized, double blind and cross-over. Twenty-seven healthy male recreational MDMA users were included. They received a single oral dose of MDMA (doses ranged from 50 to 150 mg). Physiological parameters (blood pressure, heart rate, temperature, pupil diameter), psychomotor performance (DSST and simple reaction time), and subjective effects were measured. Blood samples were obtained to determine MDMA and metabolites, and hormones (prolactin and cortisol). MDMA administration induced dose-related significant changes in blood pressure, heart rate, pupillary diameter and oral temperature. Performance measures were slightly impaired after 125 and 150 mg. MDMA induced euphoria and well-being feelings, slight changes in perceptions (sounds, lights) but no hallucinations. MDMA produced a marked increase in cortisol and prolactin plasma concentrations. A parallelism was observed between blood levels and pharmacological effects. Peak plasma concentrations were obtained at 2 hours, elimination half-life was about 8-9 hours. Cmax and AUC increased in a non-proportional way in relation to dose administered, suggesting a possible non-linear pharmacokinetics of MDMA.
Supported by grants: FIS 97/1198 and 98/0081, CIRIT 1997SGR00077, ISC-III 97-98/4344 and PNSD.