I'm not sure if this in the literature or not (probably) and I haven't really studied it yet, but...
If you have a 10kg kid with bronchospasm, what would you treatment be. I'm imagining, that in the pediatric population (and perhaps adults as well) that Epinephrine is the drug of choice. A cardiac arrest dose is 10mcg/kg, so knowing that Epi has greater efficacy for B2 receptors at lower doses, what kind of dose would you administer to the kid in the above situation?
Yea, that sounds like a good idea. Which one are you referring to? A page # would also help expidite the search for this b2 selectivity of epinephrine. A preliminary search for this selectivity has yielded me nothing, but my only source available to me is the world wide web, (all my texts are at home ). AND, as we all know, the web can be as reliable as overhearing a conversation in the bathroom so to speak, but I digress.
Take it easy on me, I'm still learning, but very interested. Have a good day!
Acetylcholine is a bronchconstrictor so giving pre-op atropine or glycopyrolate decreases intra-op bronchospasm. These are effective IV, IM, or endotracheally.
nitric oxide??? what does that have to do with anything?
NO does help with hypoxia by limiting the lungs' vasoconstrictive response to hypoxia. I think it relaxes the vascular endothelium and dilates the pulmonary vessels.
I do remember that long term NO therapy oxidizes iron and causes methemoglobinemia, which inhibits the blood's oxygen-carrying capacity.
These are the only things I can remember about NO in regards to the respiratory system.
). AND, as we all know, the web can be as reliable as overhearing a conversation in the bathroom so to speak, but I digress.
Brenna's Dad
394 Posts
Terbutaline is an IV B2 agonist, is it not?
Seems it's main use is keeping the bun in the oven though.