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Mar 13, 2004
Isoproterenol, the quarternary atropine.
Isoproterenol is a beta agonist.
Must have been tired... what i meant to say was Ipratropium.
Mar 14, 2004
nitric oxide??? what does that have to do with anything?
NO does help with hypoxia by limiting the lungs' vasoconstrictive response to hypoxia. I think it relaxes the vascular endothelium and dilates the pulmonary vessels.
I do remember that long term NO therapy oxidizes iron and causes methemoglobinemia, which inhibits the blood's oxygen-carrying capacity.
These are the only things I can remember about NO in regards to the respiratory system.
sorry about my response regarding nitric oxide... but in truth, you wouldn't use nitric oxide for bronchospasm.... but you would use Heliox...
Mar 15, 2004
Heliox being less dense and therefore creating less resistance to flow.
Law of Fives
Mar 22, 2004
The past few articles I've read in regard to using NO to treat bronchspasm did not show NO to be effective in alleviating bronchoconstriction. In fact, NO usually had deleterious effects including increased bronchial blood flow, exudation and edema, as well as direct cytotoxic effect on airway epithelial cells all of which can contribute to advancing the bronchospasm in the opinion of the researcher.
Good point Brenna's Dad, Heliox = helium plus oxygen at various ratios - the more helium used in the mixture the less dense, and there fore more effective at delivering oxygen beyond areas of bronchoconstriction. I have not come across any info on the role of helium as a bronchodilator.
Likewise, I have not found any information on the receptor selecitvity of varying dosages of epinephrine. BUT, i'm still searching
Have a good day
helium isn't a bronchodilator - but due to its lower density it can carry albuterol past spastic lung tissue for better spread and quicker alleviation of the symptoms
beta-selectivity at low-dose of epinephrine is nicely portrayed in this image - literature sources include goodman & gilman, stoelting, etc.. as well as pubmed...
Mar 23, 2004
Thanks for posting that link Tenesma. I followed it back and printed off the entire section of Adrenergic Pharmacology - very helpful
law of fives ... would you mind posting the page you got to for adrenergic pharmacology. The webpage I'm going to is telling me it doesn't exist. Thanks!
Mar 26, 2004
Thanks a lot! :)
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