Transfusion associated NEC

Specialties NICU

Published

What is your unit's policy with regards to making babies NPO for blood transfusions?

I recently transferred to a level III NICU. For the two years prior to my arrival, our unit would make babies NPO (starting or increasing IV fluid) for two hours prior to blood, transfuse, and keep NPO two hours after completion. Our neos compared the unit's data from this period to years prior and saw no change in NEC incidence but an increase in hypoglycemic episodes.

Because of this, they decided to go back to the old way of continuing feeds throughout the transfusion. This was right when I began working in the unit. Within a couple months we've had three babies die from NEC -- all PRBC transfused within the past 24 hours, all previously fed breast milk exclusively, all ex-24 weekers.

I thought keeping kids NPO was standard practice. From what I can tell, evidence points pretty strongly to the existence of TANEC, as well as its high(er) rate of mortality than NEC that's not transfusion associated. I am frankly surprised that two years worth of data from our little 40 bed unit is being valued over many years of research in academic settings and some of the meta analyses that come up at the top of every search.

Is there something I'm overlooking? It's not like I want my babies to experience hypoglycemia, but a bolus or some tweaking of IVF seems a whole lot less dire than NEC. Looking for input. Like I said, I'm pretty new to this.

We make kiddos NPO two hours prior to transfusion, infuse blood over 3-4 hours (unless emergent) and keep infant NPO 2 hours post infusion. If kiddo was eating prior to transfusion and on TPN/IL, we increase TPN rate, our IL rates do not get touched- their rates stay the same. If the kiddo doesn't have TPN/IL because they were on full feeds, we take a sugar 1/2 way through the transfusion. If kiddo is prone to being fluid overloaded or is on fluid restrictions than they would get a hit of lasix.

We continue to feed if the feeds are 50ml/kg/day or less. Any more than that and they are NPO for 3 hours before and 8 hours after. We run blood over 3 hours, so the kid ends up on fluids (clears if they aren't already running tpn/il) for the better part of a day. I haven't appreciated any sugar issues with this, we just check dex sticks per regular protocol.

We used to restart feeds at a low volume and work back up, but have recently began restarting at full feeds and we haven't seen a problem with that. I would love to see more of the research for this!

Regarding the Epogen, that's great that it seems to be working! We are in the middle of a blind trial right now to see if we are going to initiate an Epo protocol or not. We use it currently only for babies whose parents are Johovah's Witnesses.

Specializes in NICU, PICU, PACU.

The Epogen protocol is awesome! I can't begin to tell you how it has really cut down our transfusion rates.

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