pathophysiology of sepsis linked with UTI.....

Esme12, ASN, BSN, RN · May 22, 2012

welcome to! the largest online nursing community.

sepsis is a serious medical condition that is characterized by a whole-body inflammatory state. also called systemic inflammatory response syndrome or sirs, and the presence of a known or suspected infection. the body may develop this inflammatory response to microbes in the blood, urine, lungs, skin, or other tissues.

severe sepsis occurs when sepsis leads to organ dysfunction, hypotension, or insufficient blood flow hypoperfusion to one or more organs causing, lactic acidosis, decreased urine production, or altered mental status. sepsis can lead to septic shock, multiple organ dysfunction syndrome, formerly known as multiple organ failure, and death. organ dysfunction results from sepsis-induced hypotension (

i found this from the cleveland clinic....

sepsis, also known as systemic inflammatory response syndrome (sirs), is a serious medical condition caused by the body's response to an infection.

sepsis, also known as systemic inflammatory response syndrome (sirs), is a serious medical condition caused by the body's response to an infection. sepsis can lead to widespread inflammation and blood clotting. inflammation may result in redness, heat, swelling, pain, and organ dysfunction or failure. blood clotting during sepsis causes reduced blood flow to limbs and vital organs, and can lead to organ failure or gangrene (damage to tissues).

bacterial infections are the most common cause of sepsis. sepsis can also be caused by fungal, parasitic, or viral infections. the source of the infection can be any of a number of places throughout the body. common sites and types of infection that can lead to sepsis include:

the abdomen--an inflammation of the appendix (appendicitis), bowel problems, infection of the abdominal cavity (peritonitis), and gallbladder or liver infections
the central nervous system--inflammation or infections of the brain or the spinal cord
the lungs--infections such as pneumonia
the skin--bacteria can enter skin through wounds or skin inflammations, or through the openings made with intravenous (iv) catheters (tubes inserted into the body to administer or drain fluids). conditions such as cellulitis (inflammation of the skin's connective tissue) can cause sepsis.
the urinary tract (kidneys or bladder)--urinary tract infections are especially likely if the patient has a urinary catheter to drain urinehttp://my.clevelandclinic.org/disord...ic_sepsis.aspx

systemic inflammatory response syndrome (sirs). defined by the presence of two or more of the following findings:

body temperature 38 °c (100 °f) (hypothermia or fever).
heart rate > 90 beats per minute.
respiratory rate > 20 breaths per minute or, on blood gas, a pco2 less than 32 mm hg (4.3 kpa) (tachypnea or hypercapnia due to hyperventilation).
white blood cell count mm3 or > 12,000 cells/mm3 ( 12 × 109 cells/l), or greater than 10% band forms (immature white blood cells). (leukopenia, leukocytosis, or bandemia).

sepsis. defined as sirs in response to a confirmed infectious process. infection can be suspected or proven (by culture, stain, or polymerase chain reaction (pcr)), or a clinical syndrome pathognomonic for infection. specific evidence for infection includes wbcs in normally sterile fluid (such as urine or cerebrospinal fluid (csf)); evidence of a perforated viscus (free air on abdominal x-ray or ct scan; signs of acute peritonitis); abnormal chest x-ray (cxr) consistent with pneumonia (with focal opacification); or petechiae, purpura, or purpura fulminans.
severe sepsis. defined as sepsis with organ dysfunction, hypoperfusion, or hypotension.
septic shock. defined as sepsis with refractory arterial hypotension or hypoperfusion abnormalities in spite of adequate fluid resuscitation. signs of systemic hypoperfusion may be either end-organ dysfunction or serum lactate greater than 4 mmol/l. other signs include oliguria and altered mental status. patients are defined as having septic shock if they have sepsis plus hypotension after aggressive fluid resuscitation (typically upwards of 6 liters or 40 ml/kg of crystalloid solution.https://allnurses.com/general-nursing-discussion/sepsis-a-syndrome-653341.html

systemic inflammatory response syndrome or sirs is evidence of the body's ongoing inflammatory response. when sirs is suspected or known to be caused by an infection, this is sepsis. severe sepsis occurs when sepsis leads to organ dysfunction, such as trouble breathing, coagulation or other blood abnormalities, decreased urine production, or altered mental status. if the organ dysfunction of severe sepsis is low blood pressure (hypotension), or insufficient blood flow (hypoperfusion) to one or more organs (causing, for example, lactic acidosis), this is septic shock.

http://en.wikipedia.org/wiki/systemi...ponse_syndrome

http://en.wikipedia.org/wiki/sepsis usually not a wiki fan but it contains great information.

maybe not the answer you were looking for but i hope this helps.......great critical care tutorial that explains sepsis and it's treatment i think you'll like it what is sepsis?

MattNurse, MSN, RN · May 22, 2012

Sepsis causes leaky capillary beds which will cause hypo-perfusion and lower blood pressures.

-Lemon- · May 23, 2012

Hi Sophia. Like Erme was saying, what helps me think about hypotension r/t (related to) sepsis is SIRS. I just think, what is going on in localized inflammation? The same thing is going on thought out the body because the the bacteria (in most cases) is in your blood and your blood is everywhere. Inflammation releases histamines and prostaglandins among others that cause vasodilation, inflammation, fever, hypo-perfusion, Like Matt was saying leaky capillaries hence the swelling among others. Hope it helps!