Hi Sophia. Like Erme was saying, what helps me think about hypotension r/t (related to) sepsis is SIRS. I just think, what is going on in localized inflammation? The same thing is going on thought out the body because the the bacteria (in most cases) is in your blood and your blood is everywhere. Inflammation releases histamines and prostaglandins among others that cause vasodilation, inflammation, fever, hypo-perfusion, Like Matt was saying leaky capillaries hence the swelling among others. Hope it helps!