Isoniazid injection for latent TB

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Hello. Does anyone know the injection regimen for getting Isoniazid for Latent TB?? I know the pills you take for up to 6 months... can cause upset stomach, vomiting, increased liver enzymes, etc. Anyone know about the injections? How often you get them? How long the therapy is? THANKS! :redpinkhe :)

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Specializes in Emergency & Trauma/Adult ICU.

There are many quality internet drug database reference sites ...

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Thank you. Yes. I found some info. on it, but not the regimen.... how often, how long to give, etc. Was wondering if anyone here might know. Thanks...

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Specializes in ER.

active TB 5mg/kg po/im qd x8-18months

latent TB 5mg po/im qd x6-9months

renal dosing no adjustment, CrCl

hepatic dosing: in acute liver dz or INH associated liver injury is contridicated

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Ok. Thanks lckrn2pa. So you are saying IM injections EVERY DAY for SIX MONTHS?? Wow. I thought the injections would be less often and for a shorter time period. Ok. Thanks.

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Specializes in ER.

Epocrates had this dose regime, Pharmacopoeia only had the PO regime. Looking at drugs.com http://www.drugs.com/cons/isoniazid-oral-intramuscular.html also had the IM at adult/teens 300mg/qday and children weight based dosing.

The adverse reaction you mentioned in your post are included with all the antimycobacterials regardless of route of administration, so just changing from PO to IM will not alter the S/E of the drug. Biggest concern is the hepatotoxic effects but that does occur it usually resolves with prompt d/c of the drug.

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Ok. Thanks again. I was trying to figure out if by doing the shots, it would take less time with less risk. Thanks again for trying to help!

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