help me! please!

madwife2002, BSN, RN · Mar 7, 2005

What would you like the article to be on? There are millions around you need to be more specific

DDRN4me · Mar 7, 2005

there are several journals that have quantitative research articles..do you have access to Ebscohost? if so, go to CIANL thats a great start to find journals, but you really need to narrow down a topic. Good luck, i am doing a project on autism with the same focus ..

Annie111 · Mar 10, 2005

Thousands of thanks to you 2, there is no actual topic for the quantitative research article, actually, it is only to show your ability to identify a quantitative nursing research article for my assignment, and i need to print out it attached in my assessment. any good suggestions? any help great appreciate!!! have a great weekend!

Annie

madwife2002, BSN, RN · Mar 10, 2005

Select Journal or ResourceJAMA & Archives HomeJAMAArchives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Otolaryngology--Head & Neck Surgery Pediatrics & Adolescent Medicine SurgeryStudent JAMA (1998-2004)JAMA & Archives CMEJAMA CareerNetFor The MediaUsers' Guides to the Medical LiteratureMeetingsPeer Review Congress

http://jama.ama-assn.org/cgi/content/short/293/10/1212

Chromosomal Instability in Amniocytes From Fetuses of Mothers Who Smoke

Rosa Ana de la Chica, MSc; Isabel Ribas, PhD; Jesús Giraldo, PhD; Josep Egozcue, MD; Carme Fuster, PhD

JAMA. 2005;293:1212-1222.

Context Tobacco increases the risk of systemic diseases, and it has adverse effects on pregnancy. However, only indirect data have been published on a possible genotoxic effect on pregnancy in humans.

Objectives To determine whether maternal smoking has a genotoxic effect on amniotic cells, expressed as an increased chromosomal instability, and to analyze whether any chromosomal regions are especially affected by exposure to tobacco.

Design, Setting, and Patients In this prospective study, amniocytes were obtained by routine amniocentesis for prenatal diagnosis from 25 controls and 25 women who smoke (10 cigarettes/d for 10 years), who were asked to fill out a smoking questionnaire concerning their smoking habits. Chromosomal instability was analyzed in blinded fashion by 2 independent observers in routine chromosome spreads. Breakpoints implicated in chromosomal abnormalities were identified by G-banding.

Main Outcome Measures Association between maternal smoking and increased chromosomal instability in amniotic fluid cells, expressed as chromosomal lesions (gaps and breaks) and structural chromosomal abnormalities.

Results Comparison of cytogenetic data between smokers and nonsmokers (controls) showed important differences for the proportion of structural chromosomal abnormalities (smokers: 12.1% [96/793]; controls: 3.5% [26/752]; P = .002) and to a lesser degree for the proportion of metaphases with chromosomal instability (smokers: 10.5% [262/2492]; controls: 8.0% [210/2637]; P = .04), and for the proportion of chromosomal lesions (smokers: 15.7% [391/2492]; controls: 10.1% [267/2637]; P = .045). Statistical analysis of the 689 breakpoints detected showed that band 11q23, which is a band commonly implicated in hematopoietic malignancies, was the chromosomal region most affected by tobacco.

Conclusions Our findings show that smoking 10 or more cigarettes per day for at least 10 years and during pregnancy is associated with increased chromosomal instability in amniocytes. Band 11q23, known to be involved in leukemogenesis, seems especially sensitive to genotoxic compounds contained in tobacco.

Author Affiliations: Departament de Biologia Cel-lular, Fisiologia i Immunologia, Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain (Ms de la Chica and Drs Egozcue and Fuster); Centro de Patología Celular, Barcelona, Spain (Dr Ribas); and Unitat de Bioestadística, Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra (Dr Giraldo).