Help,what is the difference between PrednisoLone/Prednisone

azhiker96, BSN, RN · Mar 25, 2009

Prednisone is activated by the liver into prednisolone. For this reason, and because it is more easily absorbed, prednisolone is the drug of choice when hepatic disease or insufficiency is present.

lovehospital · Mar 25, 2009

Thanks

systoly · Mar 25, 2009

In essence, they are the same so you would look for similar side effects. The chemical formula is slightly different and dosages are slightly different, so their is an equivalency chart and,of course, what azhiker96 said.

pagandeva2000, LPN · Mar 25, 2009

Glad I saw this question...I always wondered myself.

RedCell · Mar 25, 2009

What is the difference,any one knows?

Look up the definition of what a prodrug is. Prednisone is an example of one. Many medications we give are prodrugs and the pharmacokinetics of these medications can be quite interesting.