Help me understand the role of ALBUMIN ??

Nurses General Nursing

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Specializes in Med-Surg.

I'm a little confused.. our Pharmacology book says that some drugs bind to albumin and are then carried throughout the body (at this point I'm thinking Albumin facilitates distribution) BUT that drugs that are protein bound are generally too large to pass through the walls of blood capillaries into tissues (so it doesn't facilitate distribution??).

Drugs need to get to their target cells to instigate an effect, correct? They can't do this if they're protein bound and unable to make it into tissues, correct? So if a drug is highly protein bound, it is less likely to exert its effect than a drugs that is free and unbound?? In which case, the purpose of Albumin here is ?

Can someone help me??

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Specializes in ORTHOPAEDICS-CERTIFIED SINCE 89.

http://www.merck.com/mrkshared/mmanual/section22/chapter298/298d.jsp

Look into a search engine. I checked my favorite the Merck Manual.

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Specializes in Med-Surg.
http://www.merck.com/mrkshared/mmanual/section22/chapter298/298d.jsp

Look into a search engine. I checked my favorite the Merck Manual.

Thank you, I understand it better now. I tried a search engine multiple times but kept pulling up unrelated info or research docs that were over my head. This was a clear read that really helped. I'll bookmark the site! Thanks again.

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