Critical Care Question

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What is the difference between Myasthenia Gravis vs Cholinergic Crisis?

Thank-you in advance,

StudentNurseElle

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^ This.

Also know that you treat them differently. In myasthenia gravis, there isn't enough Ach and may also be because of being undermedicated. in cholinergic crisis, there is overstimultion from too much Ach. Clinically, they both look the same - such as muscle weakness. Neostigmine is given differentiate between the two...if they improve, it's myasthenia gravis (also provide respiratory support). If they worsen, they are in a cholinergic crisis - provide respiratory support and be prepared to give some atropine.

...that's what I learned in pharm, anyway. :)

Up Vote Up Vote ×

^ This.

Also know that you treat them differently. In myasthenia gravis, there isn't enough Ach and may also be because of being undermedicated. in cholinergic crisis, there is overstimultion from too much Ach. Clinically, they both look the same - such as muscle weakness. Neostigmine is given differentiate between the two...if they improve, it's myasthenia gravis (also provide respiratory support). If they worsen, they are in a cholinergic crisis - provide respiratory support and be prepared to give some atropine.

...that's what I learned in pharm, anyway. :)

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