Contrast and Renal Failure

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What is the physiological process that causes contrast to cause renal failure?

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Not well understood. Several pathways may be involved. Why do you ask? School or work related?

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work related. Is it because the contrast is thick and blocks the tubules? Please don't laugh.

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work related. Is it because the contrast is thick and blocks the tubules? Please don't laugh.

Three broad concepts may play a role:

1) Direct toxicity

2) Hemodynamic alterations and compromised renal perfusion

3) Production of toxic substances such as free radicals

A combination of the three is also possible, and likely IMHO.

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