Can someone give a detailed explanation of Clexane, Warfarin, and Frusimide?

[davidthenurse]

Hi,

I'm a student nurse in Australia, and I'm trying to find out what the "life-cycle" of the following three drugs are:

1. Clexane by S/C injection(also known as Lovenox or Enoxaparin Sodium) - anticoagulant/antithrombitic
   
2. Warfarin orally- anticoagulant/antihrombitic
   
3. Topical GTN patches (Glyceryl trinitrate)
   

I particularly need help regarding what actually happens to these medications once they get INTO the body. For example, the step-by-step process by which the medication is absorbed (how and where), metabolised (how and where), and then excreted (how). I have been researching for these details for the last 3 hours, but with little results!!

:urgycld:

Oh, dear, maybe its just me, [sigh], but I've looked on the internet, in pharmacology books, in MIMS, etc... but not much luck.

Thanks in advance everyone!!

I can't tell you all how much I appreciate help - I would rather be humble and ask, then just guess it myself!! (besides, there's no room for guessing with medications, you have to either get it "RIGHT" or "RIGHT" with pts.)

:plsebeg: So if anyone is willing to help me out - THANKS SOOOO MUCH !!!!

[XB9S, BSN, MSN, EdD, RN, APN]

Have a look at this

CLexane

and this

I found these but searching for pharmacokinetics and pharmacodynamics of clexane. Try it with the other drugs and see what you come up with

[XB9S, BSN, MSN, EdD, RN, APN]

moved to the student assistance forums for a better reponse

[Daytonite, BSN, RN]

here is drug information from the internet site, drugs.com (http://www.drugs.com/) you can search their site for drugs by brand or generic name and it will present you with various levels of information for consumers and professionals and you choose the level you want to view. it is, however, a u.s. based website.

• lovenox (enoxaparin) - fda monograph: http://www.drugs.com/pro/lovenox.html
  
• warfarin - fda monograph: http://www.drugs.com/pro/warfarin.html
  
• topical gtn patches (comparable to transderm nitro used in the u.s.) - fda monograph: http://www.drugs.com/pro/transderm-nitro.html
  

[davidthenurse]

Hi, thanks, I'll have a look at these sites and see if I can piece the puzzle together !! :typing