Action of Loop diuretic on the Loop of Henle

- Normally, 35% of filtered NaCl is reabsorbed in the thick ascending loop of Henle.

- The asc loop transports NaCl via the Na+/K+/Cl++ symporter - this is blocked by loop diuretics.

- Prevention of NaCl reabsorption leads to increased loss of free fluid.

many of these are from pharmacology school sites:

• http://www.pharmacology2000.com/renal/renal_obj1.htm - renal pharmacology; includes a review of nephron physiology and then later on the page gives a rundown of the mechanism of action of loop diuretics.
  
• http://www.uptodate.com/patients/content/topic.do?topickey=fldlytes/25960 - mechanism of action of diuretics
  
• http://www.scribd.com/doc/257805/pharmacy-diuretics - pharmacy pharmacolgy: diuretics (a slideshow); information on loop diuretics are on slides 20 - 27. abbreviations used on the slides refer to anatomy of the nephrons and is shown on slide 51.
  
• http://www.mc.uky.edu/pharmacology/instruction/pha824dr/pha824dr.html - the pharmacodynamics of diuretic drugs
  
• http://www.skepticfiles.org/md001/loop.htm
  
• https://allnurses.com/general-nursing-student/renal-physiology-355217.html - renal physiology
  
  • "loop diuretic (organic acids) - these diuretics promote diuresis because they prevent sodium and chloride ions from being transported across the loop of henle which would normally pull them back into the circulating blood. this results in large amounts of sodium, chloride and water being pulled into the urine. loop diuretics include furosemide, butetanide, ethacrynic acid and torsemide."
    

  [*]https://allnurses.com/nursing-student-assistance/renal-system-360367.html - renal system; includes a rundown of the anatomy and physiology of a nephron.