I need a physical reminder of things that are due when, so I have a huge calendar (18x30 or something) that I handwrite in all of my assignments, my work schedule, and anything else. Everything is color coded. One class is pink, the other is purple, work is blue, and anything else is black. I check off assignments as I complete them. I could put them in my iPhone, but that just isn't enough for me.
I keep my books in a small tote bag. That way, I can carry them around the house to whatever room I've decided to work in that day (sometimes the living room, sometimes the dining room table, and sometimes the desk in the family room). This also makes it easy to grab them on my way out the door if I'm going somewhere I'll have time to read, like the laundromat.
More technology related than physical space, but here's what I do for files:
Main folder: Name of University
Inside that: 1 folder for each class
Inside class folder: 1 folder for discussion postings, 1 folder for papers, 1 folder for notes, and 1 folder for resources (journal articles, handouts, etc)
My Macbook lets me highlight the names of folders, although I don't know if Windows has the same capability. This semester's classes are highlighted in orange, next semester's are yellow. I also back up to a USB drive at least weekly.