High Dose Chemotherapy & Hemorrhagic Cystitis

Hello all!

I am required to do a nursing research / evidence-based practice project specific to my specialty area to be able to advance in my hospital's clinical ladder program. I currently work outpatient oncology & BMT. We do a lot with the BMT process, including chemo mobilization. Currently, our standard orders to prevent hemorrhagic cystitis for high dose Cytoxan is continuous bladder irrigation for 24 hours and for Ifosfamide it is Mesna. I know that Mesna is indicated for both drugs. I was wondering if some of you could relay your current practice standards for prevention of hemorrhagic cystitis. Does anyone know of any reasons why CBI may be consistently used with Cytoxan? I am trying to get to the point of preventing infection (UTI) in an already vulnerable neutropenic population.

Thank you!

Stephanie