The Hunger Games

Sometimes, the medications we take to manage acute and chronic health conditions create almost as many problems as they are prescribed to treat. Among the many possible side effects, one of the most distressing to patients is the tendency of some drugs to increase appetite and therefore contribute to weight gain. Here is a perspective on these effects from a nurse who also happens to be a patient taking one of these medications. Nurses Announcements Archive Article

`urp` groannnnnnn......

How in the name of all that is reasonable is it possible to eat this much and not blow up??! I just polished off a two-enchilada dinner, complete with salsa and chips plus a slice of flan to top it all off, and even though I feel like a beached whale I know darned well I'm going to be hungry again before bedtime.

Why? Because I'm taking a medication whose major side effects are increased appetite and weight gain. Actually, "increased" doesn't even begin to cover it: I'm eating practically everything that's not red hot, nailed down, or running for the hills. What I've consumed in the past three weeks could feed an entire Third World country for a day. Thankfully I've got only a few more doses of the stuff, so the voraciousness should soon be a thing of the past; but the way I've been Hoovering food lately, I'm shocked that I haven't gained back half of the sixty pounds I dropped over the past year. Yikes!

While in reality I've only put five of those pounds back on since I started the drug, I see a fuller face and a bloated abdomen in the mirror. I feel thick and lazy and unmotivated, like I did before I lost the weight. My appetite is so out of control, in fact, that I half-jokingly promised my family and friends that I'd never get sick for the rest of my life if it means never again having to take meds that make me wolf down everything but my shoes! (They just laughed and reminded me that I wasn't exactly in charge when this latest bout took matters to a whole new level.)

As both a nurse and patient, I would like to find out some day what makes certain medications so likely to induce overeating and weight gain, and what (if anything) can be done to change that. The irony of it all is really too much: I take one drug that stopped my lifelong habit of compulsive eating dead in its tracks (hence the weight loss), but with this one I could star in my own reality show called Extreme Eating. The fact that it is also very good at curing what ailed me makes it worth using in a crisis, but I feel sorry for people who have to take large doses or stay on it for very long.

Obviously, patient adherence to medications that increase appetite and body weight is an issue, especially over the long term, and the advice given to them is often unhelpful. It's all too easy for the prescriber or the nurse caring for the patient to say "You have to resist the temptation to overeat". It's enough of a challenge for the patient to stick with the meds knowing that no matter what she does, she is more than likely going to gain weight, without being told that she needs to "just say no".

A person who's never been on an appetite-inducing drug cannot possibly understand this ravenous hunger that literally overwhelms the patient's defenses and drives him to eat enormous quantities of food in a relatively short amount of time. There IS no "just say no"---the best that can be hoped for is to contain the number of calories consumed until such a time as he can stop taking the medication or his appetite levels off (as it sometimes does). Patient teaching needs to be directed toward keeping weight gain to a minimum by encouraging them to use foods that satisfy the "crunch" factor, such as apples and crisp vegetables, and to increase their physical activity gradually so that their appetite doesn't become even larger.

All of which is much easier said than done. Oooh, look, is that pumpkin cheesecake??

Welp this sounds exactly like my anti epileptic medication. Smh if I miss more than 2 or 3 days im in the middle of the floor shaking and unconscious. Beyond happy that I will be seeing a neuro doctor on the 16th to try and get medications changed.

I was on Paxil for a year and a half. What a nightmare! Not only did it take me 6 months to wean myself off it when I started feeling robotic, but I put on 50 lbs the first 2 months I was on it!!! Then another 10 the rest of the time I was on it! I was starving all the time. I'd finish my bf's dinner, plus eat all of mine and be STARVING a few hours later.

I gained 40lbs in 4 months on it! I recall being ravishingly hungry all hours of the day.

I was on a high dose of Prednisone that took 3 years to completely wean off of, I gained weight the first year but was able to get it off by strict dieting. However, in the 4 years I've been prednisone free my metabolism, hair, and skin have changed drastically than from their pre-prednisone state.

Anyone heard of long term effects of prednisone after extended exposure? From what I've read online symptoms should disappear after d/c but I find it hard to believe.

This is a wonderful article as it brings a very important subject up. Now just imagine those feeling you describe but it not being caused by a medication but a defect inside you! My son has a condition called Prader-Willi syndrome and these kids and adults end up needing all food locked up because they have been known to eat until they burst their stomach... Some families lock cabinets, some build a full walk in pantry that every edible item (food, toothpaste, cleaning supplies, and the garbage) must be locked 100% of the time... These kids/adults can eat a full meal and be SCREAMING in hunger! There is no cure but it is manageable with constant food security. No medications that suppress appetite work though we don't know why. Food is a miserable battle for so many in so many different situations. Great article!

I was fortunate enough to be a sitter for a teen with prader-willis on all of my shifts for 6 weeks a couple years ago. I applaud all of he hard work that it takes everyone in the family to live their lives. I saw first hand the rage that ensues from such hunger, as well as the devastating secondary health problems that went with it. I can only imagine what it must feel like for the child. I was struck twice in the face for not providing food- I wasn't allowed to. But under it all the child was sweet and loving and the time spent really touched me.

I fortunately am not on any medication. As I am getting older I find it much harder to lose weight. I work out twice as hard and eat half as much as I could in my 20s. I can see why many patients do not follow their medication and diets as prescribed.

Specializes in Psychiatric nursing.

My meds make me ravenous, I'll get home from work at midnight and eat a full meal.

I am on not 1 but 2 of weight gain/ appetite stimulating drugs. Nobody understands the battle. They tell me to eat less. Ya thanks for the tip!

Specializes in Public Health, L&D, NICU.
We treat hunger like it is something controlable, which is sometimes true. But it also can be impacted by a lot of different factors, some of them physiologic.

I took Qsymia this year and was also shocked that my lifelong binge eating immediately stopped. I felt sane around food and could make reasonable food choices. It made me wonder if this is what normal people feel like.

I just started Qsymia this week. I have immediately stopped drinking soft drinks because they all taste appallingly foul now. "Real" food doesn't taste good either, like meats and veggies and breads. Unfortunately sweets still taste awesome. Hopefully when I up my dose in two weeks that part will resolve.

Specializes in Public Health, L&D, NICU.
I've never heard of Qsymia. I will have to look it up.

I was on Paxil for a year and a half. What a nightmare! Not only did it take me 6 months to wean myself off it when I started feeling robotic, but I put on 50 lbs the first 2 months I was on it!!! Then another 10 the rest of the time I was on it! I was starving all the time. I'd finish my bf's dinner, plus eat all of mine and be STARVING a few hours later.

Qsymia is a combination of phentermine (amphetamine) and Topomax (seizure med). Many people on Topomax had weight loss as a side affect.

I keep hearing this about people on Topomax losing weight, I've been on it for years for migraines (a very high dose), and have never had that side effect. Lucky me I guess... I gained weight while taking it and had to lose it the old fashion way, exercise and portion control. I'm now at a healthy weight but it's a daily struggle. Sigh

Specializes in LTC, assisted living, med-surg, psych.
I keep hearing this about people on Topomax losing weight, I've been on it for years for migraines (a very high dose), and have never had that side effect. Lucky me I guess... I gained weight while taking it and had to lose it the old fashion way, exercise and portion control. I'm now at a healthy weight but it's a daily struggle. Sigh

Same thing happened to me on Lamictal, which is supposed to be weight-neutral. I gained 20+ pounds on it during the first few months I was taking it, then I added another 25 with Zyprexa. But I lost 'em all, plus some of their friends, after going off the 'Vitamin Z', and I've no doubt I'll be able to do it again. :yes: After Thanksgiving, anyway!

Specializes in Public Health, L&D, NICU.
I keep hearing this about people on Topomax losing weight, I've been on it for years for migraines (a very high dose), and have never had that side effect. Lucky me I guess... I gained weight while taking it and had to lose it the old fashion way, exercise and portion control. I'm now at a healthy weight but it's a daily struggle. Sigh

I took Topomax years ago for migraines, and I did have weight loss, so I'm hoping the Qsymia works. I also had weight loss on Zonegran. It was nice to lose on those two, because with nearly every other migraine preventative (and I've been on dozens) I've gained. And I crave carbs when I get a migraine (and I converted to chronic years ago), so the deck is stacked against me.