Quote from dudette10
At the risk of sounding clueless, I have to ask why renal failure and sepsis would be a contraindication to Tylenol. I've been googling, and there are plenty of links to acute hepatic failure, but not acute renal failure. (There are some links suggesting--not proving--that long-term Tylenol use can be a contributing factor in chronic renal failure.) In addition, there are order sets for sepsis that include Tylenol as an analgesic choice.
Long term acetaminophen use is possibly contraindicated for renal patients, but from what I've seen, short term use doesn't seem to be an issue. (Of note, tylenol isn't an NSAID.)