why thiazide diuretics for DI

[direw0lf, BSN]

I was reading about treatment for nephrogenic diabetes insipidous and my book says "Limiting sodium intake to no more than 3g/day often helps to decrease urine output" but it doesn't say the rationale for the thiazide diuretics and to me isn't that like contradicting? Is it because of the hypernatremia in some way? Thank you.

(This isn't a homework question! We're on the endocrine system)

[smf0903]

Here's a journal article about thiazides for DI that may help :)

JASN | Mobile

[Samm06, BSN, RN]

isn't thiazide a loop diuretic which helps produce more urine?

[smf0903]

isn't thiazide a loop diuretic which helps produce more urine?

Thiazides work at the distal convoluted tubule, whereas loop diuretics work at the loop of Henle. Different actions :)

[direw0lf, BSN]

Here's a journal article about thiazides for DI that may help :)

JASN | Mobile

Thank you I had a little trouble understanding it but I think I get the gist is that it induces antidiuresis in DI..interesting!

[Samm06, BSN, RN]

Thiazides work at the distal convoluted tubule, whereas loop diuretics work at the loop of Henle. Different actions :)

Ohhh thank you for the clarification :)

[smf0903]

Thank you I had a little trouble understanding it but I think I get the gist is that it induces antidiuresis in DI..interesting!

I was was trying to find a video that explained it better, but the one I found went way too in depth LOL. I wa having flashbacks to A&P and cellular pumps...I wasn't going to subject someone else to that LOL!!