Any info is greatly appreciated! I know the main difference is that the PICC goes to SVC tip where as the MIDLINE only goes to ax. area- but- do you need an xray for a midline confirmation placement?? and/or is the midline "not" considered a central line as the picc is?? It was a quiz question I had and the only other choice- "midlines only take hypertonic solutions and piccs only isotonic" I wasn't quite sure about these - anyone- please explain??