DIGOXIN - conflicting information! (Hypothyroidism)

[demylenated, BSN, RN]

Sry (crossposting - in med savvy I needed a mod approval?)

So, have a pharm test tomorrow. Studying my drug cards. Have 3 sources: 2010 Davis drug guide, 17th edition Medi Quick Cards by LWW, and 9th Clinical Drug therapy by Abrams.

So: DIGOXIN. I know this drug well... however, I have a questions about HYPOTHYROIDISM.

I'd like an answer before tomorrow's test, but I am 90% certain this will not be a question (but, justincase :) )

Medi Quick cards say, "Hypothyroid patients may need *larger* doses."

Clinical drug therapy monograph says, "Patients with hypothyroidism are extremely sensitive to cardiac glycosides and may need *lower* doses."

Davis' says: "Use caution in hypothyroid patients."

Hmm... conflicting for sure

Anyone with some additional data?

Thanks :) Off to study some more. Last test of the semester, and I need a 60% to maintain my "A" This is the LPN to RN transition course. I am mighty proud... or, well, I will be when I get at least a 66%

~ Demy

[EMT6530]

patients with hypothyroidism are more sensitive to this drug and therefore need a LOWER dose to avoid toxicity

[Jenni811, RN]

Go by your textbook. this way if it is in the test you are able to use the textbook to show the professor where it says that.

[wtbcrna, MSN, DNP, CRNA]

Here is the answer: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1674491/