As someone who has worked in both, I very much prefer PICU. If it's the baby thing that's got you hung up, we get a lot of babies in our unit, some brand new, particularly in the winter during RSV season. Yesterday, of the 14 patients we had, nine were infants. In general, babies in NICU will have one or two of about six common problems: prematurity, respiratory distress, transient tachypnea of the newborn, persistent pulmonary hypertension, hypoglycemia or congenital anomalies. There's not much variety, and they're pretty hands-off patients. Care is clustered so that they are left undisturbed for as much of time as possible. In fact, with some of the developmental stuff they've introduced to the NICU in recent years, you might not actually even see your patients for much of the shift because the isolette will be covered to keep the baby in the dark and quiet. PICU is a different day every day, even with the same patient. You have to be sharp to be able to move from infant to teenager to preschooler and back to infant, and the variety of problems that bring them into hospital is infinite. AND (big plus!!) they interact with you when they're better. I really like working with a range of ages and developmental levels, and having to stretch myself everyday, and that's good for me. But in the end, your decision has to be yours. It sounds like you've been involved with a wide range of age groups and are comfortable with kids in general, so maybe PICU IS the right place for you. Then again, if you thrive on routine, it's not. Food for thought?