Can anyone tell me the most recommended way to flush a PICC line? Do we have to use a 10 cc syringe or the smallest possible like a 1 cc tuberculin syringe. As what was recommended by our Interventional Radiologist to flush the PICC line with the smallest syringe specifically 1cc or 3 cc syringe with normal saline. But it's contradicting with what is normally read in written notes about care of PICC line, to flush using a 10 cc syringe. I've noticed too that PICC line easily clots. Do we have to flush them with heparin every time when not in use too? Does anybody has any idea?