Did a search and only found 2 old threads on the topic which did not address my question.
I understand protein binding / free drug. I believe that the bound drug and free drug exist in a 1:1 ratio (as free drug is "used up", bound drug becomes available to keep that balance). My question is if serum protein levels are low will the excess free drug be metabolized more quickly to reestablish a 1:1 ratio or will it be excreted to reestablish the 1:1 ratio?
Also, we were taught that lipid bound drugs remain in the body longer. Yet, I understand it works off the same principle - as free drug is used, then lipid bound drug is released to be metabolized...why does this remain in the body longer if the principle is the same? Is it merely longer to be distributed since it is not stored in the bloodstream like the protein bound drugs?
Hope the questions make sense and thanks in advance to anyone that can help.