IV ABX by pump...when can I change new bag??

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I have a question regarding IV ABX administration via pump. I am a home health nurse and a general rule I know we can't change IV ABX times, especially when given once a day. Now, I have a pt on IV Vanco 1gm in 250ml NS q12hr to infuse over 90 mins via gemstar pump. Each IV bag contains two doses (Vanco 2gm/520ml NS), with a KVO of 1ml/hr. Let's say the pump starts first infusion at 8am and second infusion at 8pm. After second infusion is complete, can the bag be changed ANY time after 9:30pm and before 8am the following day (as next dose is due)?? Or does the bag need to be changed closer to 8am the following day?? I hear co-workers saying that it can be started ANY TIME before next dose.

Hope my question made sense:confused:

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