Hep B Titer

Nurses Stress 101


Hey everyone !!

So about 4 years ago i started A job in a hospital and they required me to get all my titers drawn! They said everything looked good and i started my position. Now i has to get them all drawn again for a new position and they said my hep B was negative and i would have to get all three shots again ! How would i drop Immunity I'm four years ?? Has anyone else had this problem?

HBV FAQs for Health Professionals | Division of Viral Hepatitis | CDC

for some reason it won't allow me to copy and paste the relevant quote...it is at the end.

Specializes in Community and Public Health, Addictions Nursing.

Relevant quotes from the previous poster's website link:

"Studies indicate that immunologic memory remains intact for at least 30 years among healthy vaccinated individuals who initiated hepatitis B vaccination >6 months of age. The vaccine confers long-term protection against clinical illness and chronic hepatitis B virus infection. Cellular immunity appears to persist even though antibody levels might become low or decline below detectable levels. Among vaccinated cohorts who initiated hepatitis B vaccination at birth, long-term follow-up studies are ongoing to determine the duration of vaccine-induced immunity."


"Can anti-HBs levels following vaccination decline over time?

Yes, anti-HBs levels following vaccination decline over time. Anti-HBs ≥10 mIU/mL is considered a correlate of vaccine-induced protection for persons who have completed an approved vaccination series. Immunocompetent persons who achieve an anti-HBs level ≥10 mIU/mL 1-2 months after a complete hepatitis B vaccine series remain protected, even if anti-HBs levels decline to

From :

"Should a healthcare professional who performs invasive procedures and who once had a positive anti-HBs result be revaccinated if the anti-HBs titer is rechecked and is less than 10 mIU/mL?

No. Immunocompetent people known to have responded to hepatitis B vaccination in the past do not require additional passive or active immunization. Postvaccination testing should be done 1-2 months after the original vaccine series is completed. In this scenario, the initial postvaccination testing showed that the healthcare professional was protected. Substantial evidence suggests that adults who respond to a 3-dose hepatitis B vaccine series (anti-HBs of at least 10 mIU/ mL) are protected from chronic HBV infection for at least 22 years, even if there is no detectable anti-HBs currently. Only immunocompromised people (for example, dialysis patients, some HIV-positive people) need to have anti-HBs testing performed periodically. Booster doses of vaccine to maintain their protective anti-HBs concentrations to at least 10 mIU/mL are recommended for dialysis patients and may be given to some HIV-positive patients."

Important food for thought, though at the end of day, employer policy often trumps the evidence base.

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