Embarrassing anesthesia question that I really should know

gaspassah · Apr 30, 2004

dont worry, i didnt know it till it was taught to me. the action of succs is initially you get depolarization. when the succs molecules diffuse away the patient is usually anesthetized. there is no real stimulus to cause a second depolarization, the muscles are not stimulated to fasciculate a second time. however, the patient, if not paralyzed with a non depolarizer or a nice dose of narcs, may buck on the tube or begin moving. this may be what you saw. if you get the chance, watch the tounge after sux is administered it will solidify what a fasciculation really is. individual muscle fibers firing in an uncoordinated fashion.

also after the administration of succs, acetylcholine and succs kind of work in an agonist antagonist fashion. the succs molecules that diffuse away from the nerve terminal and are not immediately matobolized will reattach to the receptor (this is the antagonist part) and not allow a repolarization, as will excess acetylcholine. this is the mechanism of a phase II block if you give too much succs or redose too soon. if i am remembering this correctly.

d

gaspassah · Apr 30, 2004

passin gas, i stand corrected

Acetylcholinesterase metabolizes acetylcholine in the synaptic cleft into choline and acetate. Choline is reuptaken into the presynaptic neuron and reutilized. Succinylcholine terminates its action by diffusion away from the neuromuscular junction and is metabolized in the plasma by plasma cholinesterase.

in my attempt to be brief i mispoke (typed) thank you

d

m9999l · Jul 29, 2004

kaiser in pasadena. finished my pharm final last week.

I wanted to go Kaiser Permanente school of nurse anesthesia. Instead I went to another anesthesia school and now I almost regret it.

What can you tell me about Kaiser's CRNA program. I went to Pasadena and visited the school and met with the director. I can't remember his name. It was years ago. I had not even graduated from BSN school. Now I'm 5 months away from graduation from a CRNA program in Florida. The program is 28, grueling, painful, exhausting, months. I didn't go to Kaiser because I was accepted here in Florida. My entire family is here so it was better for me to stay here.

I love Pasadena. It's such a charming town. How has your experience been at Kaiser? Do you know Retta? She was the secretary at Kaiser's CRNA program.

I'm super interested to hear from you.

Virgo

zentuit · Jul 29, 2004

can anybody currently viewing tell me the correct spelling of "besiculation?" or "basiculation?" for years i thought it started with a "v!!" i can't even seem to get my spelling close enough to search for it in spellcheck or in the archives on this bb!!

just a tip but you can use google's excellent spelling checker indirectly. i do this all the time, simply hit http://www.google.com and type the word into the search box. if it can't find a match in its index (which is built from all the insane number of web pages it processes), it will return what it considers its best "guess". actually if it finds something really close it will return that in addition to the search results.

i hit google and typed in "basiculation", google returned "did you mean: fasciculation ". total time spent - less than a minute. its quite handy.

tom

Tia · Jul 29, 2004

kaiser in pasadena. finished my pharm final last week.

Must be finals week for everyone here. I am in first semseter in Kansas City and I am also due for a much needed break. I have pharm. and physiology next semester. Hope everyone's tests go well. Which I should probably be studying not posting:) Only one more day of smelling like cadaver lab!!!

Tia

UCDSICURN · Jul 29, 2004

Only one more day of smelling like cadaver lab!!!

:chuckle :chuckle :chuckle

Donn C.