Treatment for Pediatric bronchospasm - page 3
I'm not sure if this in the literature or not (probably) and I haven't really studied it yet, but... If you have a 10kg kid with bronchospasm, what would you treatment be. I'm imagining, that in... Read More
Mar 22, '04Joined: Mar '04; Posts: 90; Likes: 1The past few articles I've read in regard to using NO to treat bronchspasm did not show NO to be effective in alleviating bronchoconstriction. In fact, NO usually had deleterious effects including increased bronchial blood flow, exudation and edema, as well as direct cytotoxic effect on airway epithelial cells all of which can contribute to advancing the bronchospasm in the opinion of the researcher.
Good point Brenna's Dad, Heliox = helium plus oxygen at various ratios - the more helium used in the mixture the less dense, and there fore more effective at delivering oxygen beyond areas of bronchoconstriction. I have not come across any info on the role of helium as a bronchodilator.
Likewise, I have not found any information on the receptor selecitvity of varying dosages of epinephrine. BUT, i'm still searching
Have a good day
Mar 22, '04Joined: Jun '02; Posts: 365; Likes: 5helium isn't a bronchodilator - but due to its lower density it can carry albuterol past spastic lung tissue for better spread and quicker alleviation of the symptoms
beta-selectivity at low-dose of epinephrine is nicely portrayed in this image - literature sources include goodman & gilman, stoelting, etc.. as well as pubmed...
Mar 22, '04Joined: Mar '04; Posts: 90; Likes: 1Thanks for posting that link Tenesma. I followed it back and printed off the entire section of Adrenergic Pharmacology - very helpful
Mar 23, '04Occupation: SRNA at UNC Charlotte Joined: Aug '03; Posts: 242; Likes: 6law of fives ... would you mind posting the page you got to for adrenergic pharmacology. The webpage I'm going to is telling me it doesn't exist. Thanks!
Mar 26, '04Joined: Mar '04; Posts: 90; Likes: 1
Mar 26, '04Occupation: SRNA at UNC Charlotte Joined: Aug '03; Posts: 242; Likes: 6Quote from Law of Fives
Thanks a lot!