I had my first case of negative pressure pulmonary edema yesterday. 26 YO for a knee scope, declined SAB and LE block, she requested a general and due to her GERD/heartburn, I chose GA with ETT. I did a RSI without difficulty and the case proceded without incident. During emergance, she seemed to have a bit of difficulty coordinating her breathing, and had a couple of MINOR episodes of desaturation as I woke her up. Eventually, I extubated her when reflexive but due to her continued coughing she never truely followed commands. Her sat was 98% with evidence of good exchange occuring immediatly. Upon arrival in PACU, her sats were 89% and we placed her on a simple mask at 10 liters with sats improving to 93-95%. She had fairly severe crackles throuout and 10 mg of lasix improved things immediatly. A CXR showed a PE picture and improved over the next couple of hours. When thinking about her ETT, there was a fair amount of frothy pink sputum present. Should have sent alarm bells off sooner I guess. She was discharged home a number of hours later, happy and feeling fine. I'm looking for possible explainations. Anyone care to comment?