Was wondering if anyone has suggestions for administering cardene via IV BOLUS.... how you mix it/concentration and how much you 'bump' in at a time....



12 Posts

Specializes in Emergency.


Cardene is not to being given IV bolus it is a slow continuous infusion of a concentration of 0.1mg/ml mixed in 240cc of compatible ivf resulting in a 250ml solution (not compatible w/ sodium bicarb or LR) MUST BE DILUTED

The ampule is 25mg per 10cc

The diluted soln is good for 24 hours

Initial therapy is at 50ml/hr (5mg/hr) for rapid decrease in BP increase rate Q 5min by 25ml/hr (2.5mg/hr) up to 150ml/hr (15mg/hr) do not exceed this amount. Once desired BP reached decrease rate to 30ml/hr (3mg/hr)

If trying to gradually lower BP increase Q 15 min. until desired BP is reached

There are quite a few contraindications if you want to know those also let me know

Hope this helps

Has 13 years experience.

shouldn't be given as a least not that I've ever done/heard of...

we used it for HTN in acute CVAs

5 mg/hour, titrated up to a max of 15mg/hr

our concentration was 25 mg in a 240 cc bag of D5 1/2 NS, and start at a rate of 50 cc/hr


25 Posts

I seem to be seeing it used more at our main clinical site. We do the standard 25mg in 250ml (0.1mg/ml). Some will then draw up 10ml into a syringe and bolus 0.5-1ml increments


47 Posts

thanks ralatek for the dosing the others, I understand the FDA approves of only gtt purposes of cardene however, like many drugs in this profession, things aren't always administered under FDA guidelines or approval.

Much thanks!!!!!!!!


145 Posts

Specializes in CVICU, CCRN, now SRNA.

I would love to hear about bolus dosing, if anyone's done it.

I've only used it a couple times in CVICU and don't like it. It took me 30-60 mins to see results following dosing guidelines, then the pressure rose as soon as I decreased to the "maintenance" dose of 3mg. I ended up titrating it, but took about 4 hours to find the dose that worked best.


457 Posts

i have given it bolus by mixing in the standard fashion then drawing some in a 10 cc syringe to give by 1 ml increments. i will also free flow cardene on regular iv tubing if the patient has an art line. i use it alot for intracranial interventional radiology stuff, aneurysms and the like. it is a very safe drug and has a relatively fast half life. doesnt stick around for very long.



67 Posts

Cardene is a great short acting antihypertensive. I use it mostly during CABG, mainly when getting the pressure down for cannulation. I mix it 2cc with 8cc ns for a 0.5mg/ml concentration. I give 1/2 to 1cc at a time. I like to give a cc early in the case to get an idea of how much of a drop in bp I get. Usually 0.5 mg will give me about a 15 to 20 pt decrease in bp. It will usually last for about 10 minutes. You do get a reflex increase in hr, so watch out for that. I used it today, and it worked great. The cardene rep inserviced us on this bolus technique.

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