I really don't think you should have any problems landing a job if you are seeking one in an LTAC - there seems to always be a market for experienced nurses. Switching to acute care might be more problematic.
I would strongly advise you to make sure that you try to coordinate your efforts so that you wait to decide on a housing location until you have a job lined up -- otherwise, you could be locked into a soul-deadening commute. It's hard to offer any other advice since you did not indicate any other particulars.. where you are moving from, family situation, etc.
Welcome to Houston! Hope you like it here.