After methotrexate chemo is given, Leucovorin is ordered as a rescue drug. At the hospital I work at, the continous IVF given is a Sodium Bicarb in D5W. Our Pharmacy mixes the the IVF and Leucovorin. Leucovorin is often given in a syringe and sometimes in a 100NS bag. There is no consistency, but I know we are suppose to have it administered for about 5-15 minutes in NS. I just looked up Leucovorin in my drug book and Leucovorin is not compatible with Sodium Bicarb which I know, but as far as giving it in the syringe or IVPB in 100NS how do you guys normally do it? I feel safer giving it in the IVBP cuz sometimes I dont have the time to stand there for 5 minutes to give the push.
From Davis Drug Guide: [HTML]http://www.drugguide.com/ddo/ub/view/Davis-Drug-Guide/51439/11/leucovorin_calcium[/HTML]
reconstitute 50-mg, 100-mg, and 200-mg vials to a concentration of 10 mg/mL; reconstitute 350-mg vial to a concentration of 20 mg/mL
Administer by slow injection over a minimum of 3 min; not to exceed 160 mg/min