Pharm question

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Ok, this is one of my objectives and I just can't find the answer anywhere. I don't have to turn this in or anything, it's just for my own studying, but I really would like it to make sense. So here's the question.

Discuss drug-drug interactions and identify which are pharmacokinetic (results in higher than expected serum levels of one of the drugs) and which are pharmacodynamic (produce a change in response without affecting serum levels).

If nobody knows I will try and get my question answered in class, but hoping someone can explain this in plain english, lol

Teresa

mittels

126 Posts

If you give me an example of 2 different meds, it may be more helpful to discuss this further.

TeresaRN2b

550 Posts

Originally posted by mittels

If you give me an example of 2 different meds, it may be more helpful to discuss this further.

That's the thing, it didn't give any drug examples. Perhaps they just want us to be able to do that within specific drugs. I am not sure. This is all very foreign to me.

Teresa

mittels

126 Posts

Well lets try this one:

milk of mag. Dont give to renal insufficiency, or use cautiously.

The answer to your pharmokinetic question lies in your contraindications section in your drug book.

milk of mag. Dont give with with tetracyclines. reduces the bodies ability to absorb the drug therefor; making it useless. This would be in you interactions section of your drug book.

pharmokenetic=contraindicaitons

pharmacodynamic=drug to drug interactions

hope this helps

CPB

33 Posts

Pharmacokinetics is the study of what the body does to the drug. Pharmacodynamics is the study of what the drug does to the body. So---In other words, pharmacokinetics is where the med is absorbed, how it is distributed, how it is metabolized and how it is eliminated. Pharmacodynamics are the different actions of the drug-----ASA (aspirin) for example has an antiinflammatory, analgesic, antipyretic, and antiplatelet action. Hope this helps. I don't know if you have a drug reference already or not, but I have the Prentice Hall's Nurses Drug Guide for 2002 and both of these things are listed in the description of all of the drugs.:)

CPB

33 Posts

Okay, so I just realized that I didn't answer your question at all. All I can find is a description of drug-drug interactions, but no examples or explanations of which are pharmacokinetic or pharmacodynamic.

Drug- Drug interaction- when an individual is taking two medications that are highly protein bound, the medications compete for binding sites to these proteins. This competition results in either less of both drug, or less of one of the drugs binding to the protein. In return, more unbound drug is left floating around. This process leads to an unexpected drug response (drug-drug interaction). So I guess what this is saying in a nutshell is that a drug- drug interactions can either decrease or increase the response of another drug that has been administered at the same time.

THIS IS A TOUGH ONE!

athomas91

1,093 Posts

there are a few drug-drug interaction categories...

synergystic

additive

antagonist

and one more....

TeresaRN2b

550 Posts

Originally posted by athomas91

there are a few drug-drug interaction categories...

synergystic

additive

antagonist

and one more....

I am thinking that this is maybe where they are going with this question. Catagorizing the types of drug interactions as pharmacokinetic or pharmacodynamic, but still not sure. I will see what I find out in class.

Teresa

TeresaRN2b

550 Posts

Oh and thanks everyone for your help. I appreciate it!

Teresa

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