H5N1, Bird Flu Updates - page 8

Tracking Bird Flu Cases Bird flu deserves its own thread for tracking suspected and confirmed cases. It's not the pandemic virus, but it is still an ongoing and significant threat because of its... Read More

  1. Visit  indigo girl profile page
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    Egypt

    http://www.flutrackers.com/forum/sho...9&postcount=10

    Sadly, according the following translation, the child in the post above has died:

    Quote from www.flutrackers.com

    Died today, Wednesday, Hassan Ali Mohamed (4 years) a resident in the village fled Center launched a BPA Beni Suef, after suffering from bird flu.

    أعلن الدكتور مجدى حزين، مدير إدارة الطب الوقائى بمديرية الصحة ببنى سويف، أن الطفل قد دخل مستشفى بنى سويف العام فى الثامن عشر من مارس الحالى، وهو يعانى من أعراض مرضية مثل ارتفاع درجة الحرارة، ورشح من الأنف، والتهاب رئوى حاد، وأعلن مساء الأحد الماضى عن إصابته بالمرض حيث أعطاه الأطباء عقار التاميفلو، وتم تحويله إلى مستشفى منشية البكرى بالقاهرة، ولكنه فارق الحياة اليوم بالمستشفى.

    Dr. Magdy sad, Director of the Department of Preventive Medicine Department of Health Beni Suef, that the child has entered Beni Suef General Hospital on the eighteenth of March, which is suffering from symptoms such as high temperature, runny nose, pneumonia, and announced on Sunday evening the past from the illness, where doctors gave him Tamiflu, and evacuated to a hospital in the capital Cairo, but he died today in hospital.

    http://translate.googleusercontent.c...hQlRv7j5BUY5oA
  2. Visit  indigo girl profile page
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    Banke, Nepal

    http://www.nepalnews.com/main/index....-in-banke.html

    Quote from www.nepalnews.com
    District Livestock Services Office, Banke confirmed the prevalence of bird flu in the district on Tuesday after it received a report from the central laboratory in Kathmandu.

    It had sent samples of poultry products after over 150 chickens and ducks died in a short span in Binauna, Kohalpur, Phattepur and Nepalgunj.

    Authorities have started taking special measures to control the virus from spreading. They have declared Chacharpharka of Binauna – 4 as the ‘hotspot” and decided to kill and desterilise poultry and poultry products in and around the area.
    (hat tip crofsblog)
    Last edit by indigo girl on Mar 25, '10
  3. Visit  indigo girl profile page
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    Tulcea, Romania

    http://www.flutrackers.com/forum/sho...26&postcount=2

    Quote from www.flutrackers.com
    Specialists ANSVSA samples were collected from two chickens suspected of disease and they have sent to the Institute for Diagnosis and Animal Health, to be subsequently transmitted to the Community Reference Laboratory for Avian Influenza Weybridge in the UK.

    ...Romanian authorities confirmed the existence of an outbreak of highly pathogenic avian influenza type H5N1 in village Letea, Tulcea County.
  4. Visit  indigo girl profile page
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    Nilphamari, Bangladesh

    http://www.thefinancialexpress-bd.co...?news_id=96161

    Quote from www.thefinancialexpress-bd.com
    Thousands of poultry birds affected by avian influenza viruses in the district were culled last week.

    Stamping out of 3,000 avian influenza affected poultry birds had been completed in a single farm in Ramnagar Union Parishad of Sadar Upazila in the district.

    When contacted, Noor Islam, district livestock officer, Nilphamari, told The FE that even the eggs of the affected poultry farms were also destroyed.
  5. Visit  indigo girl profile page
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    Damietta Governate, Egypt

    http://www.flutrackers.com/forum/sho...11&postcount=4

    From a translation over at flutrackers, this would be the 108th confirmed human case of H5N1 infection for that country.

    Quote from www.flutrackers.com
    The Ministry of Health on Sunday said the discovery of new human case of bird flu, bringing the total number of cases in Egypt since the emergence of the disease and so far 108 cases.
    وأوضحت الوزارة فى بيان لها أن الحالة الجديدة لسيدة من محافظة دمياط تبلغ من العمر 30 عاما وحالتها حرجة.


    The ministry said in a statement that the new situation of a woman from Damietta Governorate at the age of 30 years and in critical condition.


    وأضاف البيان أن السيدة دخلت مستشفى صدر دمياط يوم 25 مارس / اذار الحالى تعانى من ارتفاع شديد فى درجة الحرارة وسعال وصعوبة فى التنفس، وذلك عقب تعرضها لطيور منزلية يعتقد فى إصابتها بفيروس إنفلونزا الطيور.


    The statement added that Ms. Damietta was entered hospital on March 25 this suffers from high temperature, cough and difficulty in breathing, following exposure to household birds, believed to be infected with avian influenza.

    وأشار البيان إلى أنه تم إعطاء السيدة عقار (تاميفلو) وتم تحويلها إلى مستشفى صدر العباسية لاستكمال علاجها.

    The statement pointed out it was given Ms. drug (Tamiflu) was transferred to the hospital was the Abbasid to complete treatment.
  6. Visit  indigo girl profile page
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    Vietnam: More on the latest H5N1 survivor

    http://crofsblogs.typepad.com/h5n1/2...-survivor.html

    Quote from crofsblogs.typepad.com
    The woman from Soc Son District in Ha Noi was hospitalised on March 10 with a high fever and respiratory failure, five days after developing flu-like symptoms.

    Many of her organs had begun to fail and her blood had begun to coagulate because she had been admitted to hospital too late, medical staff said.

    "Two hours after checking in to hospital, her condition began to deteriorate very rapidly so we decided to filter her blood with the aid of polymyxin-B (Pmx-B) [a type of antibiotic] that was the result of a scientific research co-operation project between Bach Mai Hospital and the Japan International Medical Centre," said Dr Nguyen Gia Binh, director of the Intensive Care Department.

    Health authorities said the H5N1 virus was growing increasingly resistant to Tamiflu.
    http://pandemicinformationnews.blogspot.com/

    Translated article:

    Quote from pandemicinformationnews.blogspot.com
    Vietnam: Survival of patients severe influenza A/H5N1 by dialysis
    [A bit more on the 25 yo from Hanoi, that successfully beat H5N1]

    (02/04/2010)
    Dan - good luck this case the patient T. Nguyen Thi Thu (25 years) in Soc Son, Hanoi. This is influenza A/H5N1 patients had complications viscera failure was saved by using results filtering method was first applied in Vietnam.

    The tests showed that the disease has turned the organ failure: respiratory failure, circulatory failure, kidney failure, blood clotting disorders, metabolic disorders, severe infections.

    In the treatment of patients influenza A/H5N1, scientists have warned very clearly: Tamiflu works well when used within 48 hours after virus penetration body. Accordingly, Dr. Nguyen Gia Binh - Dean of intensive care, Bach Mai hospital - because she said T. too late to hospital, five days after the influenza A/H5N1 virus, so treatment with antiviral drug Tamiflu have very little effect. Not to mention, with a weak condition after birth (she is raising children Vol 3 months), patients face a high risk of death.

    The doctors have decided to combine the treatment with Tamiflu use continuous dialysis method, using special filtering effect adsorption of toxins in the blood reduces the inflammatory response.

    After 10 days of treatment, patients used three filtering effect and gradually recovered health. This morning, Ms. T. was discharged.

    This is influenza A/H5N1 patients had complications viscera failure was saved by using results filtering method was first applied in Vietnam. It is known that adsorption filter result is the invention of Japanese scientists, effects and filters to keep the toxins circulating in the blood, reduces the organ injury. Price per fruit is 3.500USD filter.
    Read full post and comments
  7. Visit  indigo girl profile page
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    egypt: 34 h5n1 deaths

    http://crofsblogs.typepad.com/h5n1/2...n1-deaths.html

    Quote from crofsblogs.typepad.com
    via daily news egypt: bird flu death toll reaches 34. excerpt:

    egypt's ministry of health announced the 34th bird flu-related death in the country, an 18-year-old woman from fayoum.
    this comes one week after minister of health hatem el-gabaly lauded the success of the government's plan in combating bird flu (h1n5), explaining that the death rate from the virus has substantially decreased while citizen awareness has increased.
    "the government has been dealing with the issue with complete transparency and sincerity, as well as a commitment to giving the highest quality treatments at the hospitals," the minister told the people's assembly last week.

    the number of bird flu cases witnessed a hike in 2010; the 18-year-old is the seventh reported this year. a total of 109 cases have been reported since the virus first appeared in egypt in 2006.

    egypt's h1n5 death rate stands at 6.3 percent, lower than the global rate of 7.61 percent, the ministry said in a statement last week.

    i don't understand that "6.3 percent" death rate. thirty-four deaths out of 109 confirmed h5n1 cases means a case fatality ratio of 31.1 percent. that's awful, but it's still enormously better than indonesia's 82.8 percent.
  8. Visit  indigo girl profile page
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    vietnam

    http://afludiary.blogspot.com/2010/0...-flu-case.html

    Quote from afludiary.blogspot.com
    the patient, trung van hoa, 22, from na tao hamlet, nhu co commune, cho moi district, is currently in critical condition. he is being treated at the central hospital for tropical diseases.

    the patient got sick on march 30 with symptoms of high fever and cough. he was admitted to bac kan provincial hospital, and then sent to the central hospital for tropical diseases on april 3 where he tested positive for the lethal strain of a/h5n1 virus.

    at present, four other people in nhu co commune show similar symptoms of high fever and cough. they are under quarantine and being treated at bac kan provincial hospital.
  9. Visit  indigo girl profile page
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    All eyes on Vietnam for potential human bird flu cluster

    http://www.scottmcpherson.net/journa...u-cluster.html

    Clusters are interesting. Human to human spread of a highly pathogenic organism is of great concern, and that is why we continue to watch H5N1, bird flu. Thus far, there has been little human to human transmission although it has happened on occasion between family members. When it does occur, it is very alarming, and merits close attention.

    We also worry about two different influenzas co-infecting the same host and exchanging genetic information. In countries where H5N1 is endemic, such as Egypt, Indonesia, Vietnam and China, continued observation for that possibility is ongoing. Hopefully,
    this will never happen...

    Quote from www.scottmcpherson.net
    The patient in question was taken ill on the 30th of March, and then sent to Hanoi when his condition worsened. The four suspected human bird flu cases are currently in quarantine at the provincial hospital in the provincial capital of Bak Kan...

    There are many unanswered questions. The most obvious of these is whether these four suspected cases are bird flu, or swine flu?

    If these cases are indeed bird flu, has there been human-to-human chain transmission, or were these people all infected during the same timeframe by a single vector? Were they all infected by sick poultry, or were they sickened by a human infection?

    OK, let's assume these four people were all H1N1/swine flu infections. That is not good news! That would mean that, once again, bird flu and swine flu had "rubbed elbows" in rural Vietnam. Search my Blogsite for the earlier known case, back in 2009.

    According to the Vietnamese Department of Preventive Medicine and the Environment, there are no outbreaks of H1N1 anywhere in Vietnam.

    ...it is becoming apparent that Vietnam, more than any other nation save Egypt, may have the potential to be that flashpoint where H5 and H1 reassort. Vietnam has had, to date, prior to this report, 5 bird flu cases with 2 deaths. Egypt, in contrast, has had 18 human bird flu cases with 6 deaths. Both areas are of huge concern.
  10. Visit  indigo girl profile page
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    Cold Fronts Linked to Bird Flu Outbreaks in Europe

    http://www.alertnet.org/thenews/newsdesk/LDE63621S.htm

    New and interesting info on how H5N1 has spread in Europe. It is true that it is almost exclusively found in the wild birds of that continent.

    Quote from www.alertnet.org

    Leslie Reperant of Princeton University in the United States and Thijs Kuiken of the Erasmus Medical Centre in the Netherlands said their findings offered a possible way to predict and control where and when bird flu might erupt again.

    "Forecasts predicting near-freezing temperatures in Europe may act as an indication for concern," they wrote.
    They found that most H5N1 outbreaks occurred at sites where maximum temperatures were between 0 degrees Celsius and 2 degrees Celsius. This was usually on the edge of cold fronts where fresh water remained unfrozen.
    "Many wild waterbirds need unfrozen bodies of fresh water in winter to feed," they wrote.

    "To minimise the distance flown, they also try to stay as close as possible to the northern breeding grounds to which they will migrate during spring...The resulting congregation of different species of waterbirds along the freezing front likely created ideal conditions for the transmission of the H5N1 virus."
    (hat tip crofsblog)
  11. Visit  indigo girl profile page
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    Egypt: H5N1 Isolated In Donkeys

    http://afludiary.blogspot.com/2010/0...n-donkeys.html

    More bad news about a wiley pathogen that we continue to worry about because we, as a species have no immunity to it. Remember, the 1918 H1N1 that killed millions? The case fatality ratio was only 2% for that flu while H5N1, bird flu is over 50%.

    Quote from afludiary.blogspot.com
    The highly pathogenic H5N1 is a major avian pathogen that crosses species barriers and seriously affects humans as well as some mammals. It mutates in an intensified manner and is considered a potential candidate for the possible next pandemic with all the catastrophic consequences.

    We demonstrated that H5N1 jumped from poultry to another mammalian host; donkeys. Phylogenetic analysis showed that the virus clustered within the lineage of H5N1 from Egypt, closely related to 2009 isolates. It harboured few genetic changes compared to the closely related viruses from avian and humans. The neuraminidase lacks oseltamivir resistant mutations. Interestingly, HI screening for antibodies to H5 haemagglutinins in donkeys revealed high exposure rate.
    Conclusions

    These findings extend the host range of the H5N1 influenza virus, possess implications for influenza virus epidemiology and highlight the need for the systematic surveillance of H5N1 in animals in the vicinity of backyard poultry units especially in endemic areas.
  12. Visit  indigo girl profile page
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    3 BP Deletion in Donkey H5N1 In Egypt

    http://www.recombinomics.com/News/04...nkey_H5N1.html

    Thinking about what this means makes me a little bit queasy. H5N1 is not going away, and the fact that it continues to infect new mammalian hosts is worrisome. And those mild cases are very concerning because we don't know what that means, but all suspect, it is not really good news...

    Quote from www.recombinomics.com
    ...The HA and NA sequences from A/equine/Egypt/av1/2009 have been placed on deposit at Genbank and the HA sequence has the 3 BP deletion previously reported in mild cases in Egypt.

    The milder cases were first noted in 2007 and then attracted considerable interest because of the large number of mild cases in young children in 2009. The sequences from these milder cases contained the 3 BP deletion, raising concerns that the deletion allowed for efficient spread of H5N1 in humans, which was largely undetected because of the mild nature of the infection.

    The discovery of this H5N1 in mild infections of donkeys raises significant concerns. H5N1 has not been reported in equine previously, although its host range includes many mammalian species. The potential role of the 3 BP deletion raises concerns that H5N1 may be much more widespread in humans. The same deletion has been reported in clade 7 in China, raising additional concerns of human infections.
  13. Visit  indigo girl profile page
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    3 bp deletion in donkey h5n1 links to h1n1

    http://www.recombinomics.com/news/04...h5n1_h1n1.html

    Quote from www.recombinomics.com
    in addition, the equine isolate lacks aa s145. this deletion is also present in all other viruses grouped into 2.2 sublineage a1, which also includes sequences from human h5n1 isolates (fig. 2). the significance of this deletion is unknown, but it should be noted that this position is close to a domain modulating receptor interaction.

    interestingly, strains with this deletion appear to evolve towards a receptor usage that is similar to that of the seasonal human h1n1[31].

    the above comments are from the paper, “isolation and characterization of highly pathogenic avian influenza virus subtype h5n1 from donkeys” and notes the prior paper on h5n1 in egypt which identified sequences with the 3 bp deletions as those most likely to have a high affinity for human h1n1 receptors. sequences with the deletion were of interest because they were linked to mild cases of h5n1 in egyptian children in 2007 and 2009. the sequences in 2007 included closely related sequences in southern egypt, raising concerns of human to human transmission. these concerns increased in 2009 when virtually all initial confirmed cases were mild and in toddlers.

    it was at this time in early 2009 that the h5n1 was isolated from donkeys, a/equine/egypt/av1/2009, and as noted above had the same deletion. moreover, the donkeys were only symptomatic for three days and there were no fatalities. further serological analysis indicated the h5n1 was widespread in donkeys in the beni suef governorate, and therefore were likely throughout egypt because in 2009 the h5n1 with deletion was the most common h5n1 sub-clade detected in egypt in humans and poultry, including waterfowl.

    the detection of h5n1 in donkeys raised concerns that h5n1 was also in horses and camels as well as other mammals, including humans, but was not described because of a lack of testing / reporting,
    which extends to other regions and sub-clades.

    the identical 3 bp deletion was also found in china in clade 7 in shanxi and hunan province in 2006, raising concerns of widespread transmission in mammals in china including humans. the lack of testing / reporting increases those concerns. the mild nature of many of the cases in egypt raise concerns of silent spread and recombination in humans or other mammals co-infected with ph1n1, giving rise to more recombinants including h5n1 which is more transmissible in humans, or h1n1 which is more lethal in humans.
    note: ph1n1 refers to swine flu. it has for the most part, replaced seasonal flu across the globe. co-infection of hosts with swine as well as bird flu, h5n1 is a great concern. if bird flu in its milder form is truly that widespread in egypt, then this may be worth following. hard to forget, the egyptians culling all of their pigs in a panic at the beginning of the swine flu pandemic...
    Last edit by indigo girl on Apr 21, '10

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