I've worked as agency at a HealthOne hospital but know a bunch of nurses that have worked in both systems. Denver has three major health systems and I work for the other one. From what I see they are all roughly equivalent in that they are large money making machines that have a corporate outlook. Salaries seem to be highest at Exempla but they all have similar working conditions, benefits (except Exempla is owned by a catholic organization that has put some limitations on employee coverage), and pt ratios. I haven't worked at either hospital you mentioned. I would say if you are just looking to cash a paycheck you can do fine at either system. If you are looking for a career you might do better at University or Childrens, both fine hospitals that I've heard nurses speak highly of. Best of luck.