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Dipyridamole (Persantine)



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Jan 13, 2009 09:35 PM

Dipyridamole (Persantine)


I am looking up medication classifications and as I come across Dipyridamole (Persantine) its classification is Antiplatelet. I thought it was used for a stress test. How are these two related? The MOA "Exact mechanism unknown inhibits platelet adhesion; dilates coronary arteries".

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3 Comments
No. 1
from athena55
Old Jan 13, 2009, 10:49 PM

Default Re: Dipyridamole (Persantine)
Hello BostonNurse:
Yes, you are correct. Persantine or Dipyridamole inhibits thrombin formation when given long term and causes vasodilation when given in high doses for the short-term.
1) Used to lower pulmonary HTN without big drop in SBP
2) inhibits formation pro-inflammatory cytokins
3) increases release of t-PA from the brain's microvascular endothelial cells
4) increases myocardial perfusion and left ventricular function in patients with ischemic cardiomyopathy
5) used for patients with brain attack/stroke to inhibit plt aggregation or clumping (see # 2)
athena
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No. 2
from BostonNurse6
Old Jan 13, 2009, 11:00 PM

Default Re: Dipyridamole (Persantine)
Where did you get this information OR is this what you already know in your 33 years of working
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No. 3
from athena55
Old Jan 17, 2009, 10:09 PM

Default Re: Dipyridamole (Persantine)
Boston:
Gosh, I wish I could say detailed information like that I gathered from my years as an RN. Waaay back in the day when my hospital first starting doing fem-pop bypass or fem-fem bypass this was the drug of choice (mid-70's)
--> Studying for the CCRN, attending the Army critical care 8A nurse course .
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