Dipyridamole (Persantine)

Jan 13, 2009 08:35 PM

by BostonNurse6

I am looking up medication classifications and as I come across Dipyridamole (Persantine) its classification is Antiplatelet. I thought it was used for a stress test. How are these two related? The MOA "Exact mechanism unknown inhibits platelet adhesion; dilates coronary arteries".

*athena55* · Jan 13, 2009, 09:49 PM

Re: Dipyridamole (Persantine)

Hello BostonNurse:
Yes, you are correct. Persantine or Dipyridamole inhibits thrombin formation when given long term and causes vasodilation when given in high doses for the short-term.
1) Used to lower pulmonary HTN without big drop in SBP
2) inhibits formation pro-inflammatory cytokins
3) increases release of t-PA from the brain's microvascular endothelial cells
4) increases myocardial perfusion and left ventricular function in patients with ischemic cardiomyopathy
5) used for patients with brain attack/stroke to inhibit plt aggregation or clumping (see # 2)
athena

BostonNurse6 · Jan 13, 2009, 10:00 PM

Re: Dipyridamole (Persantine)

Where did you get this information OR is this what you already know in your 33 years of working

*athena55* · Jan 17, 2009, 09:09 PM

Re: Dipyridamole (Persantine)

Boston:
Gosh, I wish I could say detailed information like that I gathered from my years as an RN. Waaay back in the day when my hospital first starting doing fem-pop bypass or fem-fem bypass this was the drug of choice (mid-70's)
--> Studying for the CCRN, attending the Army critical care 8A nurse course .

New To Site	Need Help	Quick Links
Create An Account General Site Map allnurses.com Journals Terms Of Service Privacy Policy Testimonials Meet Our Staff Advertising Information	Information Center & FAQ Boards of Nursing How-To Video Tutorials Did you forget your password? Compare Membership Contact allnurses.com Text Version Mark All Sections As Read	United States Nursing International Nursing Nursing Specialty Advanced Practice Nursing Critical Care Nursing Nursing Specialties Get In Touch... Find Us On Facebook Follow Us On Twitter

Dipyridamole (Persantine)

Dipyridamole (Persantine)

Nursing News

California Imposes Stricter Rules Regarding Drug Abuse In...

Are older nurses being forced out of the profession?

An outlook in California?

Australian surgeons successfully separate conjoined twins

Disruptive behavior by doctors, nurses persists a year...

Woman sues after police tackle her in ER during premature...

Beyond The Last Lecture -For Randy & Jai Pausch nurses...

WHO: Give at-risk groups anti-flu drugs early

Nursing, medical schools should work together, experts say

Army nurse honored after 100th birthday

Available Topics (tags)